Primary Antitubercular Meds

Question 1

List the primary antitubercular meds

Answer 1

Isoniazid (INH), Rifampin (Rifadin), Ethambutol (Myambutol), Pyrazinamide (PZA)

Question 2

Which primary anti-TB meds can be given for prophylaxis?

Answer 2

INH, Rifampin

Question 3

Impt Information for Primary Anti-TB meds:

Answer 3

• Use all 4 in combo
• Adjust after C&S results
• Airborne iso for at least 2 weeks
• Monitor for compliance
• PT ed: take as ordered at same time daily
• entire prescription should be finished even if feel better
• May need to take w food to decr GI upset
• Notify provider for s/s fatigue, yellowing of skin or eyes, or hot, painfully swollen joints
• photosensitivity may occur, wear sunscreen

Question 4

Isoniazid (INH)

Answer 4

MOA: inhibits cell wall synthesis and interferes w metabolism
CAUSES VIT B6 DEF (peripheral neuropathy), LIVER TOXICITY
Contraindicated w/ use of CLOPIDOGREL
A/E: hepatitis, neuropathy
Can be used prophylactically

Question 5

Rifampin (Rifadin)

Answer 5

MOA: inhibits protein & RNA synthesis
A/E: RED-ORANGE OR BROWN SECRETIONS, makes birth control INEFFECTIVE, hepatitis, abd pain, diarrhea, heartburn
Can be used prophylactically

Question 6

Ethambutol (Myambutol)

Answer 6

MOA: inhibits protein synthesis

A/E: OPTIC NEURITIS and BLINDNESS, hepatitis

Question 7

Pyrazinamide (PZA)

Answer 7

MOA: may inhibit lipid and nucleic acid synthesis

A/E: hepatotoxicity, GOUT

Question 8

PPD Test

Answer 8

test for TB
raised after 48-72 hours= positive
redness is not indicative of positive
X-ray to diagnose current infection
If have the vaccine, PPD will be positive 
Blood draw can be used for those pts ^^

Question 9

Antitubercular (not primary) Med

Answer 9

Bedaquiline (Sirturo)
Indication: MDR-TB (in conjunction w other meds)
Monitor LFTs
A/E: h/a, chest pain, nausea, QT prolongation, arthralgia, joint pain
TAKE W FOOD to incr absorption