Antilipimics

Question 1

Statin Meds

Answer 1

-Statin
Pravastatin, simvastatin, atorvastatin, rosuvastatin
MOA: inhibits HMG CoA reductase (which is used by liver to produce cholesterol)
Most POTENT LDL REDUCERS
A/E: GI disturbances, rash, h/a, myopathy, rhabdomyolysis, elevation in liver enzymes, abd pain
AVOID GRAPEFRUIT
CATEGORY X

Question 2

Bile Acid Sequestrant Meds

Answer 2

Cholestyramin (Questran), Colestipol (Colestid), Colesevelam
MOA: prevent reabsorption of bile acids from small intestine. Bile acids are necessary for absorption of cholesterol
A/E: CONSTIPATION, heartburn, nausea, belching, bloating
Can lead to bowel obstruction- INCR FIBER/ FLUID INTAKE
TAKE OTHER MEDS 1 hr before or 6 hrs after this drug
May decr ADEK vitamin absorption (fat-soluble vitamins)

Question 3

Vitamin B med

Answer 3

Niacin (Nicotinic Acid)
MOA: incr activity of lipase which breaks down lipids, decr lipoprotein synthesis, releases histamine -> incr gastric motility + bile acid secretion
High doses required when used as antilipemic
Effective, inexpensive, often used in combo
NOT first-line, not typically well-tolerated
Can take aspirin to help with A/E
A/E: flushing (caused by histamine), pruritis, GI distress

Question 4

Fibric Acid Derivative Meds

Answer 4

gemfibrozin (Lopid)*, fenofibrate (Tricor)
MOA: primarily effects triglycerides. unknown MOA. decreases LDL
A/E: abd discomfort, diarrhea, nausea, blurred vision, h/a
DONT take with anticoagulants or statins
Incr risk of gallstones, incr bleeding risk, incr liver enzymes

Question 5

Good cholesterol is

Answer 5

HDL

Question 6

Bad cholesterol is

Answer 6

LDL