Pretest transplant/immuno/onc

Question 1

Where does TNF come from?

Answer 1

endotoxin-activated monocytes/macrophages

Question 2

How is a cross-match performed?

Answer 2

by adding recipient serum and complement to donor cells (T cells, B cells, or monocytes)

Question 3

Without ______ from helper T cells, there is no clonal expansion of alloantigen-directed cytotoxic T cells and no stimulation of antibody production by B cells

Answer 3

interleukin 2

Question 4

What does cyclosporine A primarily inhibit?

Answer 4

IL2 production

Question 5

potential sequela of CMV infection?

Answer 5

Gastrointestinal (GI) ulceration and hemorrhage

Question 6

Model for End-stage Liver Disease (MELD) score components?

Answer 6

total bilirubin, international normalized ratio, and creatinine

Question 7

______ is the treatment of choice for severe acute rejection that does not respond to steroid treatment.

Answer 7

Muromonab-CD3

Question 8

most useful serum marker for detecting recurrent disease after treatment of nonseminomatous testicular cancer?

Answer 8

hCG

Question 9

Histologic grading reflects the degree of ______ of tumor cells.

Answer 9

anaplasia

Question 10

What is tumor staging?

Answer 10

the extent of spread

Question 11

Most common abdominal malignancy of childhood?

Answer 11

Wilms tumor/nephroblastoma

Question 12

WAGR syndrome

Answer 12

Wilms tumor, Aniridia, Genitourinary anomalies, and mental retardation

Question 13

WAGR syndrome chromosomal abnormalities

Answer 13

deletion of 2 contiguous genes, WT1 (Wilms tumor

gene) and PAX6 on chromosome band 11p13

Question 14

Beckwith-Wiedemann syndrome

Answer 14

an overgrowth disorder that results in gigantism, macroglossia, hypoglycemi, and
hemihypertrophy + Wilms tumor

Question 15

MEN1 syndrome

Answer 15

pituitary, parathyroid, and pancreatic tumors

Question 16

Wilms tumor, Aniridia, Genitourinary anomalies, and mental retardation

Answer 16

WAGR syndrome

Question 17

an overgrowth disorder that results in gigantism, macroglossia, hypoglycemi, and
hemihypertrophy + Wilms tumor

Answer 17

Beckwith-Wiedemann syndrome

Question 18

deletion of 2 contiguous genes, WT1 (Wilms tumor

gene) and PAX6 on chromosome band 11p13

Answer 18

Wilms Tumor –> WAGR or Beckwith-Wiedemann syndrome

Question 19

pituitary, parathyroid, and pancreatic tumors syndrome

Answer 19

MEN1 syndrome

Question 20

medullary thyroid carcinomas (MTC), pheochromocytoma, mucosal neuromas, gangliomas, and a Marfan-like habitus syndrome?

Answer 20

MEN2B

Question 21

MEN2A

Answer 21

medullary thyroid cancer, pheochromocytomas or adrenal medullary hyperplasia, and primary hyperparathyroidism

Question 22

Early-stage seminomas should be treated with?

Answer 22

orchiectomy and external beam radiation

Question 23

MEN2B

Answer 23

medullary thyroid carcinomas (MTC), pheochromocytoma, mucosal neuromas, gangliomas, and a Marfan-like habitus

Question 24

medullary thyroid cancer, pheochromocytomas or adrenal medullary hyperplasia, and primary hyperparathyroidism syndrome?

Answer 24

MEN2A

Question 25

Tx for low-grade mucosa-associated lymphoid tissue (MALT) lymphoma w/o spread?

Answer 25

abx to treat H. pylori