Pretest transplant/immuno/onc Flashcards
Where does TNF come from?
endotoxin-activated monocytes/macrophages
How is a cross-match performed?
by adding recipient serum and complement to donor cells (T cells, B cells, or monocytes)
Without ______ from helper T cells, there is no clonal expansion of alloantigen-directed cytotoxic T cells and no stimulation of antibody production by B cells
interleukin 2
What does cyclosporine A primarily inhibit?
IL2 production
potential sequela of CMV infection?
Gastrointestinal (GI) ulceration and hemorrhage
Model for End-stage Liver Disease (MELD) score components?
total bilirubin, international normalized ratio, and creatinine
______ is the treatment of choice for severe acute rejection that does not respond to steroid treatment.
Muromonab-CD3
most useful serum marker for detecting recurrent disease after treatment of nonseminomatous testicular cancer?
hCG
Histologic grading reflects the degree of ______ of tumor cells.
anaplasia
What is tumor staging?
the extent of spread
Most common abdominal malignancy of childhood?
Wilms tumor/nephroblastoma
WAGR syndrome
Wilms tumor, Aniridia, Genitourinary anomalies, and mental retardation
WAGR syndrome chromosomal abnormalities
deletion of 2 contiguous genes, WT1 (Wilms tumor
gene) and PAX6 on chromosome band 11p13
Beckwith-Wiedemann syndrome
an overgrowth disorder that results in gigantism, macroglossia, hypoglycemi, and
hemihypertrophy + Wilms tumor
MEN1 syndrome
pituitary, parathyroid, and pancreatic tumors
Wilms tumor, Aniridia, Genitourinary anomalies, and mental retardation
WAGR syndrome
an overgrowth disorder that results in gigantism, macroglossia, hypoglycemi, and
hemihypertrophy + Wilms tumor
Beckwith-Wiedemann syndrome
deletion of 2 contiguous genes, WT1 (Wilms tumor
gene) and PAX6 on chromosome band 11p13
Wilms Tumor –> WAGR or Beckwith-Wiedemann syndrome
pituitary, parathyroid, and pancreatic tumors syndrome
MEN1 syndrome
medullary thyroid carcinomas (MTC), pheochromocytoma, mucosal neuromas, gangliomas, and a Marfan-like habitus syndrome?
MEN2B
MEN2A
medullary thyroid cancer, pheochromocytomas or adrenal medullary hyperplasia, and primary hyperparathyroidism
Early-stage seminomas should be treated with?
orchiectomy and external beam radiation
MEN2B
medullary thyroid carcinomas (MTC), pheochromocytoma, mucosal neuromas, gangliomas, and a Marfan-like habitus
medullary thyroid cancer, pheochromocytomas or adrenal medullary hyperplasia, and primary hyperparathyroidism syndrome?
MEN2A
