Pretest Flashcards
How does losing the ileum put someone at increased risk of nephrolithiasis?
Ileum reabsorbs FAs. WIthout ileum, more fatty acids reach the colon where they combine with Ca2+, leaving free oxalate to be reabsorbed. Excess oxalate is excreted by kidneys forming calcium oxalate stones
Aspirin toxicity can lead to metabolic acidosis. It also leads to resp alkalosis?
resp alkalosis -hyperventilation (increase pH, decrease pCO2) driven by direct stimulation of respiratory center
Someone presents with bleeding, normal PT, PTT and bleeding time, but decrease fibrinogen & plt count hours after surgery. What to suspect
suspect error in surgical control of blood vessels in bleeding during early postop period
Acute mesenteric ischemia without peritoneal signs –> next step? Acute mesenteric ischemia w/ peritoneal signs –>
Acute mesenteric ischemia w/o signs –> angiography
Acute mesenteric ischemia w/ peritoneal signs –> celiotomy
Worry about what when you have large blood tx without FFP and plts
dilutional thrombocytopenia & deficiency in factors V and VIII
What are the 3 metabolite disturbances when you start refeeding someone who is super malnourished. Why does this happen
refeeding –> rise in insulin in response to carbs –> electrolytes are shifted intracellularly –> hypokalemia, hypomagnesemia, hypophosphotemia.
-most common cause of death is cardiac arrhythmia
Factors that predispose to fistula formation and poor healing
Foreign body Radiation Inflammation or Infection Epithelization Neoplasm Distal obstruction Steroids
Also output > 500 cc/day
Billroth I vs Billroth II
Billroth I: operation in which the pylorus is removed and the proximal stomach is anastomosed directly to the duodenum
Billroth II: operation in which the greater curvature of the stomach is connected to the first part of the jejunum in end-to-side anastomosis.
After sigmoid resection, 10 d later, pt develops left flank pain, decreased urine output, leukocytosis. CT shows left hydronephrosis but not abscess. Suspect and do what?
IV pyelogram for suspected ureteral injury
Post-thyroidectomy w/ tingling sensation in hands, anxious, muscle cramps. What to suspect? How to treaT?
parathyroidectomy
treat with IV calcium
+ chovstek sign, prolonged QT on EKG, trosseau sign -suspect
hypocalcemia
if you give someone too much Normal saline, what kind of metabolic disturbance can you get?
NS actually has 154 mEq/L of both Na+ and Cl-
When given in large amts, can overload kidneys’ ability to excrete Cl- ion –> acidosis
How to manage someone with large ostomy outputs?
LIke large outputs from NG tube, worry about metabolic disturbances like hypokalemia, acidosis so manage with fluid replacement and stool bulking agent
Stresses increase metabolic rate. How much do these following situations increase metabolic rate?
- multiple organ failure
- 3rd degree burns involving 60% of BSA
- postoperative
- multiple organ failure - 1.5x
- 3rd degree burns involving 60% of BSA - 2.0x
- postoperative -1.1x
Pt with a trach who develops significant bleeding from tracheostomy. Most likely a sentinel blood from which artery? What to do about it?
- sentinel bleed from tracheoinominate artery fistula with greater than 50% mortality rate
- attempt to reintubate pt –> OR
List 5 situations that make for reasonable attempt at extubating a pt
- rapid shallow breathing index btw 60-105 *** RR/Vt
- negative inspiratory force should be at least greater than 20 cm H20
- wean pt to 5 cm H20 PEEP
- minute ventilation
Which inhalational anesthetic to avoid bc of accumulation in air-filled cavities during general anesthesia
nitrous oxide (low solubility, less dense than air)
ARDS: what you find on CXR what is PaO2/FiO2 pulmonary wedge pressure What are the 3 major physiologic alterations
CXR: b/l pulm infiltrates
PaO2/FiO2: less than 200
pulm wedge pressure normal at
What does low, mod, high doses of dopamine do?
t1/2 of dopamine is about 1 min so often given as an IV drip
@ all doses, dopamine increases coronary blood flow
low: vasodilation of renal and mesenteric vasculature, mild vasoconstriction of peripheral bed redirecting blood flow to kidneys and bowel
mod: B1 receptor activity predominates –> increased inotropy –> increased CO and BP
high: a1 receptor –> peripheral vasoconstriction shifting blood from extremities to organs, decrease kidney function, HTN
What’s the pharm agent of choice for a failing heart in that it can increase CO without creating too high a myocardial oxygen demand?
dobutamine is an inotropic agent of choice in cardiogenic shock as a b agonist it improves cardiac performance in pump failure both by increasing inotropy and peripheral vasodilation with minimal chronotropic effects
An epidural catheter for pain relief can cause respiratory acidosis, increased somnolence. What to do?
d/c epidural catheter
can also treat with iv naloxone
For local anesthetic, what’s the maximal safe total dose of lidocaine? What does epinephrine do?
4.5 mg/kg
epinephrine can double the infiltration anesthesia, and increase maximal safe total dose by 1/3 by decreasing rate of absorption
Neurogenic shock (hypotensive and bradycardic) -what to do?
fluid then vasoconstrictors like dopamine or phenylephrine
What’s a reliable indicator of alveolar ventilation?
PaCO2 b/c highly efficient at diffusing
Alveolar hypoventilation has what ABG finding
resp acidosis, hypoxemia and hypercarbia
Pts with PE, pulmonary edema, signficant atelectasis have what ABG findings
significant hypoxemia but normal pCO2 or hypocarbia b/c can hyperventilate to compensate so a resp alkalotic picture
Malignant hyperthermia is characterized by fever, tachycardia, increased O2 consumption, increased CO2 production, hyperkalemia, myoglobinuria, acidosis, rigidity. How to treat?
termination of surgery
100% oxygen
IV dantrolene
Urine alkalinization
Someone develops hyperkalemia after induction. What’s the suspect?
succinylcholine -a depolarizing NM blocker can increase K+ up to 1.0 mEq/L w/in a few min
Pancuronium is a muscle relaxant and is assoc with what side effect
tachycardia
If someone needs volume status to be monitored and assess for need of dobutamine. What can be used to monitor
pulmonary artery catheter
Wasting of intrinsic muscles of hands, weakness and pain at wrist -which nerve is involved
ulnar
briefly go thru the 3 processes of wound healing
1) inflammation: rapid influx of neutrophils then 2 d by mononuclear cells.
2) proliferation: angiogenesis and collagen formation fibroblasts enter in day 3)
3) remodeling: @ 2-3 wks, type 3 –> type 1 collagen
Mohs surgery vs wide local excision -any differences in cure rate?
no difference
When should you excise areas of third/deep second degree burns?
3-7d after injury
There are 3 main topical agents used to treat burns. List then and their assoc side effects
1) silver nitrate: electrolyte abnormalities, methemoglobinemia (hyponatremia, hypokalemia, hypocalcemia, hypochloremia)
2) silver sulfadiazine: neutropenia
3) mafenide: metabolic acidosis 2/2 to inhibition of carbonic anhydrase
Clefts of the lip and palate -may need speech therapy. When is the rough time period in which these should be fixed?
lip repair in 1st 3 months
palate at 12-18 months
what is a marjolin ulcer?
a squamous cell carcinoma that develops in a chronic wound such as previous burn scars or a sinus tract
Compartment syndrome -what pressure is diagnostic
> 30 mmHg
What are 3 wounds that should not be closed?
1) elapsed time to presentation > 6 hrs
2) dirty wounds or contaminated (animal bites)
3) traumatic wounds (puncture, gunshot, crush)
Skin lesion that is described as rolled, with pearly borders that doesn’t have a precursor lesion, has slow growth rate
basal cell
Someone presents with painless ulceration over left medial malleolus with surrounding brawny induration. What is it and how to treat?
venous stasis ulcers
treat with leg elevation, compression stockings and local wound care
Trauma with CXR showing air fluid level in LLL field. You put in NG tube and it coils upward into the left chest. What to suspect
acute diaphragmatic rupture –> OR for lap
If someone has complete transection of common bile duct, what to do?
If pt is stable –> choledochojejunostomy
If pt is unstable –> can place a T tube
What are things that require formal neck exploration?
- acute signs of airway distress (stridor, hoarseness, dysphonia)
- visceral injuries (subcut air, hemoptysis, dysphonia)
- hemorrhage (expanding hematoma, unchecked external bleeding)
- neuro deficits
- hemodyn unstable with neck injury
Blunt abd trauma with upper abd pain, n/v. UGI series shows total obstruction of duodenum with a COILED SPRING APPEARANCE in 2nd and 3rd portions. This is classic for? How to manage?
Classic for duodenal hematoma that presents as a proximal bowel obstruction w/ abd pain and sometimes a palpable mass.
Initial management is observation and NG suction; usu self-resolves
30 male is stabbed in the arm without evidence of vascular injury. Which structure is most likely injured if pt cannot flex his 3 radial digts?
median nerve
someone with CO poisoning with throbbing headache, n/v, dizziness, visual disturbance. Get carboxyhb level and it’s at 31% what to do?
100% oxygen until COHb
Dobutamine is the inotropic agent of choice for cardiogenic shock, but what if pt is refractory. What to do next
mechanical circulatory support with intra-aortic balloon pump
Why do you have to worry about the eyes in someone with electrical burns
can result in cataract development
Any gunshot wounds below T4 should have exp lap b/c often assoc with intraabd injuries. When should you do exp thoracotomy?
1) 1500 mL of blood removed on initial chest tube placement
2) persistent bleeding at rate of 200 ml/h for next 4 hrs or 100 ml/h for 8 hrs
If there’s crepitus in soft tissue, suspect anaerobic infections. What to do?
prompt surgical debridement and IV abx
Cardiac contusion from MVC is most common of all cardiac injuries, usu in persons who sustain direct blow to sternum. How to manage
Get EKG, put on tele for 24-48 hrs, ECHO
If hemo stable, no need for ICU
Tension pneumo is treated first with needle decompression where?
2nd intercostal space mid-clavicular
Lactate in LR is metabolized to what by the liver
bicarb
What is pneumatic anti-shock gargment (PASG)?
inflatable overalls with 3 compartments (2 for legs, 1 for the abdomen) used to elevate BP by increasing PVR. beneficical for controlling bleed from pelvic fractures by decreasing pelvic volume and immobilization to restrict fracture movement.
Absence of sepsis, how to manage enterocutaneous fistulas
initially treated non-operatively with bowel rest, TPN and correction of electrolyte abnormalities
How come small bowel fistulas (stomach to mid-ileum) are less likely to close than distal fistulas?
b/c they tend to produce a high output and therefore less likely to close
In repairing a vascular problem (for ex, GSW to left thigh causing 5 cm portionof fem artery to be destroyed), when do you do primary anastomosis vs vein graft?
if 5 cm is destroyed, it’s impossible to perform tension free primary anastomosis and therefore a vein graft is repair of choice
Diagnostic peritoneal lavage has largely been replaced by FAST in assessing for intraabd injuries. What 4 conditions of DPL necessitate exp lap?
1) aspiration of 10 cc of gross blood initially
2) > 100,000/microL of RBC
3) > 500/microL WBC
4) increased amylase, bilirubin or alk phosp
Pulm contusion wont show up on CXR initially. It is hemorrhage and edema of lung parechynma without parencyhmal disruption. How to manage?
supportive
- pain management
- pulm toilet
- maintenance of good O2
Tracheobronchial injuries can lead to
pneumothorax subcut emphysema pneumomediastinum hemoptysis resp distress
If someone has laryngeal obstruction, what’s the choice of intubation?
cricothyroidotomy