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Ageing > Prescribing In The Elderly > Flashcards

Prescribing In The Elderly Flashcards

1
Q

Acidic drugs need what sort of environment?

A

Acidic for absorption

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2
Q

Basic drugs need what sort environment for absorption?

A

Basic

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3
Q

Examples of acid drugs?

A

Phenytoin
Aspirin
Penicillins

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4
Q

Examples of basic drugs?

A

Diazepam
Morphine
Pethidine

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5
Q

Do elderly patients have an increased or decreased gastric pH?

A

Increased - less acidic - means they absorb basic drugs better than acidic

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6
Q

Is albumin acidic or basic and what does it Bind to?

A

Basic

Binds to acidic drugs

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7
Q

Is alpha -1- acid glycoprotein acidic or basic and what does it bind to?

A

Acidic

Binds to basic drugs

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8
Q

In what proportion do elderly patients have albumin and A-1-AG?

A

Low albumin

Higher A-1-AG

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9
Q

Elderly people’s liver function?

A

Reduced due to decreased liver size, blood flow and disease

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10
Q

Do elderly people have increased or decreased GFR ?

A

Decreased

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11
Q

Does narrow therapeutic window become bigger or smaller as person gets older?

A

Smaller

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12
Q

What quantifies narrow therapeutic window?

A

<2

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13
Q

Which drugs have a narrow therapeutic window?

A 
Theophylline
Warfarin 
Lithium
Digoxin
Gentamicin
Vancomycin
Phenytoin
Cyclosporin
Carbamazepine
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14
Q

What type of drug interactions exist?

A 
Drug drug
Drug food
Drug disease
Drug side effects
Drug toxicity
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15
Q

Clopidogrel and what?

A

PPIs

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16
Q

ACEi increase hypoglycaemic effect of what?

A

Sulfonylureas

17
Q

TCAs and what?

A

Type 1 anti-arrhythmic

18
Q

Theophylline and what?

A

Macrolide antibiotics

19
Q

Statins and what ?

A

Macrolides

Fibrates

20
Q

Dementia and what?

A

Gingho Bilbba

21
Q

OA and what?

A

Glucosamine

22
Q

Depression and what?

A

St. John’s wort

23
Q

Asthma and what?

A

Beta blockers

24
Q

Parkinson’s and what?

A

Drug induced confusion

25
Q

Constipation is worsened by?

A

Calcium
Anticholinergics
CCB

26
Q

What drugs lower seizure threshold?

A

Neuroleptics
Tramadol
Quinolones

27
Q

What do grade fruit, Apple, orange, cranberry Inge react with and why?

A

Statins
Antihistamines

Cytochrome P450

28
Q

What does chicken, turkey, milk, soy, cheese, yoghurt interact with and why?

A

Antibiotics
Thyroid meds
Digoxin
Diuretics.

Alter the pH

29
Q

What do bananas , oranges, green leafy veg interact with and why?

A

ACEi
ARBs
K sparing diuretics

K+ Rich

Ageing (7 decks)

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