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Reproduction > Prescribing in pregnancy > Flashcards

Prescribing in pregnancy Flashcards

1
Q

What is the standard dose of folic acid given 3mths prior and 3mths post conception?

A

-folic acid 400mcg

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2
Q

What anti-hypetensive drugs are teratogenic?

A

ACE inhibitors/ARB Renal hypoplasia

B blockers may inhibit foetal growth in late pregnancy

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3
Q

What hormonal drugs are avoided in pregnancy?

A

Androgens Virilisation of female foetus

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4
Q

Why are cytotoxic drugs avoided in pregnancy?

A

Multiple defects, abortion

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5
Q

What DMARD is avoided in pregnancy?

A

Methotrexate Skeletal defects

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6
Q

What ACNE drug is avoided in pregnancy?

A

Retinoids Ear, cardiovascular, skeletal defects

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7
Q

What anticoagulant drug is avoided in pregnancy?

A

Warfarin Limb and facial defects

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8
Q

What anti-epileptic drugs are avoided in preganncy? what folic acid supplementation is given?

A

¥ Avoid valproate, phenytoin

¥ Folic acid 5mg daily

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9
Q

What diabetes drug is dangerous in pregnancy?

A

¥ Sulfonylureas not safe

Ð Convert to insulin

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10
Q

What is used for:

  • nausea and vomiting
  • UTI
  • Pain
  • Heartburn
A

¥ Nausea and vomiting
Ð Cyclizine safest

¥ UTI
Ð Amoxicillin or cefalexin

¥ Pain
Ð Paracetamol

¥ Heartburn
Ð Antacids

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11
Q

Who recieves thromboprophylaxis in pregnancy?

A

¥ Those with significant risk factors should receive thromboprophylaxis with LMWH

¥ 2 or more risk factors eg obesity, age>35yrs, smoking, para >3, previous DVT, Caesarean delivery

¥ given at delivery and up to 7 days post-partum

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12
Q

How is VTE treated in pregnancy?

A 
¥	Treat suspected or established DVT or PE with therapeutic dose LMWH
Ð	Avoid warfarin in early pregnancy
¥	Teratogenic
Ð	Avoid warfarin in late pregnancy
¥	Risk of haemorrhage during delivery
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13
Q 
How can:
amiodarone
cytotoxics
benzodiazepines
bromocriptine
affect breastfeeding?
A

Ð Amiodarone – neonatal hypothyroidism

Ð Cytotoxics – bone marrow suppression

Ð Benzodiazepines – drowsiness

Ð Bromocriptine – suppresses lactation

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14
Q

Which antibiotic given during pregnancy or in early childhood can cause staining of teeth and bones

A

Tetracycline – also avoid in children up to 8yrs

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15
Q 
Which ‘drug’ taken in excess in early pregnancy could have cause facial appearance of :
•	Short palpebral fissues
•	Flat midface
•	Short nose
•	Indistinct philtrum
Thin upper lip
A

Alcohol – fetal alcohol syndrom

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16
Q

Which anti-epileptic drug is particularly associated with cleft lip and palate?

A

Phenytoin

17
Q

Which drug taken during pregnancy can cause vaginal adenocarcinoma in female offspring?

A

Stilbestrol

18
Q

Which anti-epileptic drug is particularly assoc. with neural tube defects (spina bifida and anencephaly)

A

valproate

Reproduction (34 decks)

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