Prescribing Flashcards
Acidic drugs require an acidic/basic environment for absorption?
Acidic drug needs acidic environment
and vice versa
Older patients have increased/decreased gastric pH? What does this mean for the absorption of acidic drugs?
Older patients have increased gastric pH (i.e. more alkaline)
Thus, acidic drugs are less commonly absorbed
What is the function of protein binding of drugs?
Required so that the drug is carried to the area it needs to act
Protein binding of drugs - which protein binds to acidic drugs
- alpha-1 acid glycoprotein
- albumin
Albumin (since it is basic)
Protein binding of drugs - which protein binds to basic drugs
- alpha-1 acid glycoprotein
- albumin
Alpha-1 acid glycoprotein
since it is acidic
A drug with a large volume of distribution will have a long/short half life?
Long
Name an example of a lipophilic drug?
Diazepam
Lipophilic drugs stay in the system for a long/short time?
Long time
In older people, it is easier to metabolise and excrete drugs. True or false?
False
Older people generally need higher/lower doses of medication?
Lower doses
A patient is unable to take levothyroxine and calcium at the same time of day. What is done to resolve this issue?q
Take one in the morning and the other at night
Side effect categories of polypharmacy
Anti cholinergic side effects
Bowel side effects (constipation)
Cognition and consciousness side effects
Dizziness and balance side effects
Why should you not combine beta blocker with CCB
Symptomatic heart block
Which anti-emetic is known to exacerbate parkinsonism?
Metoclopramide
