Prenatal sex differentiation & intersex Flashcards
Do females appear to require external instruction to differentiate in a female direction?
No
Early gonads are called _____: have potential to be either ____ or ____ for about __ weeks
bipotential, ovaries or testes, 6 weeks
Male embryos must ___ intrinsic (female default) developmental program
override
____ is a gene that produces a protein that causes the bipotential (neutral) gonads to become testes
SRY
What do the testes secrete to cause the Mullerian duct system to regress and disappear?
AMH
Is the Mullerian duct system for the female or male?
Female
Is the wolffian ducts for the female or male?
Male
What do the testes produce that prevent the degeneration of wolffian ducts and directs them to make male reproductive tract?
androgens especially testosterone
is CAH for females or males?
Females
With CAH what hormone does the body not make enough of? What does that then lead to?
- cortisol
- leads to an excess production of androgen hormones like testosterone
There is not enough cortisol to stop the overproduction of testosterone
Is Androgen insensitivity syndrome for males or females?
Males
In simple terms, what is AIS?
It is when the testosterone is there/being produced but it is not being heard by androgen receptors
Is the Mullerian duct system regressed in AIS?
Yes, it still is regressed!
With AIS do the external genitalia follow the “default” pathway to female or do they look how they are supposed to for a male
- They follow the “default” pathway
