Premature Ovarian Insufficiency Flashcards
1
Q
What is premature ovarian insufficiency?
A
menopause <40
2
Q
What are causes?
A
Usually idiopathic
iatrogenic - surgery (oophorectomy)
chemo
radio
3
Q
What are the natural causes
A
chromosome abnormalities
FSH receptor gene polymorphisms
4
Q
How is a diagnosis made
A
FSH >25IU/l – 2 samples >4 weeks apart + 4 months of amenorrhoea,
must confirm menopause
5
Q
why is FSH increased in POI
A
¥ No feedback of oestrogen to the pituitary so FSH just gets higher and higher
6
Q
What is the management
A
Oestrogen replacement:
Ð HRT until 51
Ð COCP
Androgen replacement (mainly for libido) - testosterone gel
