Preload and afterload Flashcards
What is cardiac Output?
definition?
what is it proportional to?
equation?
Cardiac output (CO) – volume of blood ejected from the heart per minute
Proportional to how often the heart beats per minute (heart rate, HR) and how much blood is ejected per beat (Stroke volume, SV)
CO = HR x SV
CO of RHS and LHS
Cardiac output from right side (via pulmonary artery) and left side (via aorta) are the same
CO and BP
relation?
equation?
Cardiac output determines blood pressure and blood flow BP = CO x TPR Blood flow (CO) = BP / TPR
can cardiac output change? why?
Cardiac output changes according to demand :
rest 70 bpm x 70 ml = 5 litres/min
Vigorous exercise 180 bpm x 120 ml = 22 litres/min
what controls Stroke Volume? (4) and how?
Preload - Stretching of heart in diastole, increases SV - Starling’s law (relates to filling pressure)
Heart rate – Sympathetic and parasympathetic nerves
Contractility – Strength of contraction at a given diastolic loading, due to sympathetic nerves + circulating adrenaline increasing [Ca2+ ]i
Afterload – Opposes ejection, reduces SV - Laplaces law (increase in pressure means heart has to work harder to eject blood)
what is energy of contraction?
what does it depend on?
Energy of contraction is the amount of work
required to generate stroke volume
Depends on Starling’s Law and Contractility
Function of Stroke Work (2)
(1) Increases chamber pressure > aortic pressure (isovolumetric contraction) (to open valve for ejection)
(2) Ejection
preload + afterload relation to energy of work
Preload
‘Increases’ energy of contraction therfore Enhances SV
Afterload
‘Requires’ greater energy of contraction so Opposes SV
Starling’s Law of the heart
what is it in relation to?
what kind of property is it?
‘Energy of contraction of cardiac muscle is
proportional to the muscle fibre length at rest’
Greater stretch of ventricle in diastole (resting muscle), greater energy of contraction, greater SV achieved in systole (contracting muscle)
Intrinsic property of cardiac muscle (nerves, hormones etc. not involved)
Why does stretching a muscle mean greater energy of contraction?
stretching a muscle fibre at rest will mean its longer therefore it can contract even more (become shorter) therefore there is a greater energy of contraction hence more SV
effect of a large intravenous infusion
effect on SV and BP
CVP (central venous pressure will increase) hence increased venous/blood voume return to heart due to increase blood volume via intravenous perfusion
therefore an increased SV (also EDV and ESV increased) as increased ejection of blood
also increased aortic BP due to increased blood volume
summary of increase blood volume + starlings law
increased venous pressure
therfore increased end-diastolic volume
therefore increased stretch of heart at rest
increased strength of cardiac contraction
increased stroke volume
describe the initial stage of starling’c curve/ventricular function curve
at normal resting filling pressure, ↑↓ CVP has considerable change in SV
describe the plateau stage of starling’c curve/ventricular function curve
as ↑CVP, ↑SV but eventually reach a plateau stage where you have stretched the heart to max and can’t produce any ↑ contraction therefore no ↑SV
describe the descending part after the plateau stage of starling’c curve/ventricular function curve
clinical importance?
excess filling can lead to an overstretched heart muscle which leads to decrease in SV
HENCE is a consideration when giving fluids as you don’t want to overfill (this will be a fluid challenge)
Fluid challenges with starling law and curve
must find out where patient is on the starling’s curve before giving fluid as you don’t want to give fluids at high CVP stage and lead to overstretching
dehydration and starling curve
where on curve? effect on curve in relation to starlings law?
dehydration means decreased CVP therefore you can give fluid as it will be on the ascending limg of the curve therfore lead to increased SV due to increased blood volume and stretch of heart
This will lead to increased CO and better filling or organs and will make you feel better
molecular level explanation for how does stretching increase energy of contraction?
what is the issue with un-stretched fibre and why weaker contraction?
whats different with stretched fibre? why stronger contraction? what other mechanism does stretched fibre have for stronger contraction?
Un-stretched fibre
Overlapping actin/myosin hence there is Mechanical inference therefore Less cross-bridge formation available for contraction
Stretched fibre
Less overlapping actin/myosin hence there is Less mechanical inference when actin + myosin come together which means MORE slide in filament hypothesis AND Potential for more cross-bridge formation AND more shortening hence MORE contraction
ALSO, stretched fibre has Increased sensitivity to Ca2+ ions therefore don’t need as much rise in Ca2+ for contraction
Both mechanisms lead to MORE contractions
Preload - Roles of Starling’s Law (5)
how does it prevent fluid congestion in heart? effect of haemorrhage? importance of postural hypotension? cvp? exercise?
Balances outputs of the RV and LV – Very important!
Prevents fluid congestion in heart
Responsible for fall in cardiac output following
a drop in blood volume
(e.g. haemorrhage, sepsis)
Responsible for fall in cardiac output during orthostasis (standing)
leading to postural hypotension (dizziness, fainting)
Restores cardiac output in response
to intravenous fluid transfusions
Contributes to increased cardiac output during exercise
Hence breakdown of Starling’s law will contribute
to development of cause heart failure
Starling Law role - balance output of RV and LV
what does this mean and if it doesnt happen, problem?
if more blood returns to the RHS, more leaves the RS, more returns to the LS, more ejected from the LS to the body hence input=output
If this isn’t done, it can lead to congestion and heart failure as blood volume centred in chambers where it shouldn’t be
Starling Law role - fall in CO following fall in blood volume
why? effect of this?
due to less venous return therefore there is less stretch of heart muscle therefore there is less SV and less CO therefore less blood to end organs
(less blood go in therefore less blood goes out)
Starling Law role - fall in CO when standing
why and effect of this?
due to less venous return to heart due to gravity when standing therefore there is less stretch of heart muscle therefore there is less SV and less CO therefore less blood to brain which makes you feel dizzy
Starling Law role - increased CO during exercise
More blood venous return to the heart hence more stretch of muscle therefore more SV and more CO
What is afterload?
what is it determined by? significance of this?
Afterload opposes ejection of blood from the heart
Afterload is determined by Wall Stress - force through the heart wall
More energy of contraction needed to overcome Wall Stress to produce ejection
Heart doesn’t function as efficiently with Wall Stress