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Phy Pharm LEC > (Prelim) Introduction > Flashcards

(Prelim) Introduction Flashcards

1
Q

Investigation of physical and chemical properties of drug molecules.

A

Pharmaceutics

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2
Q

Design, fabrication, and evaluation of Drug Delivery Systems

A

Pharmaceutics

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3
Q

Monitoring of how the drug is absorbed, distributed, metabolized, and excreted in the body

A

Pharmaceutics

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4
Q

INVESTIGATION OF PHYSICAL AND CHEMICAL PROPERTIES OF DRUG MOLECULES.

A

PHYSICAL PHARMACY

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5
Q

Physical form

A

Physical Properties

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6
Q

Particle size

A

Physical Properties

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7
Q

Melting point

A

Physical Properties

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8
Q

Solubility & Dissolution

A

Physical Properties

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9
Q

Partition Coefficient

A

Physical Properties

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10
Q

Refractive index

A

Physical Properties

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11
Q

Specific Gravity

A

Physical Properties

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12
Q

Chemical structures

A

Chemical Properties

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13
Q

Optical Activity

A

Chemical Properties

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14
Q

Polymorphism

A

Chemical Properties

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15
Q

Ionization

A

Chemical Properties

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16
Q

Complexation and Protein
binding

A

Chemical Properties

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17
Q

most often a formulation of the drug with various excipients

A

dosage form

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18
Q

administered to a patient as a specific drug product which is a particular dosage form.

A

drug

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19
Q

can be formulated in a variety of dosage forms and can be administered in different routes of administration

A

Drug products

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20
Q

Drugs that are administered in a certain route should be __________ in order for them to become bioavailable to the systemic circulation.

A

absorbed

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21
Q

Monitoring of how the drug is absorbed, distributed, metabolized, and excreted in the body.

A

PHARMACOKINETICS

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22
Q

8 mg/L

A

peak concentration

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23
Q

1.5 hours

A

time of peak

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24
Q

ADBE

A

Absorption, Distribution, Biotransformation, Excretion

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25
Q

Study of the physicochemical properties of drugs and their proper dosage form as related to the onset, duration, and intensity of drug action

A

BIOPHARMACEUTICS

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26
Q

2 types of solid in Physical Form

A

Crystalline Solid
Amorphous Solid

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27
Q

most common solid

A

Crystalline Solid

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28
Q

distinct melting point

A

Crystalline Solid

29
Q

boiling point 190°C-192°C

A

Crystalline Solid

30
Q

wider melting point

A

Amorphous Solid

31
Q

not repeated arrangement of atoms

A

Amorphous Solid

32
Q

different melting point

A

Amorphous Solid

33
Q

180°C - 190°C

A

Amorphous Solid

34
Q

affect the stability & pharmacokinetics drugs

A

particle size

35
Q

polar & non-polar

A

Solubility & Dissolution

36
Q
  • equilibrium
  • forces of attraction: higher
  • 190°C- 192°C
A

Melting Point

37
Q

determine substance purity

A

Melting Point

38
Q

measure of drug concentration in nonpolar organic phase relative to the polar aqueous phase

A

Partition Coefficient

39
Q

hates water and loves lipids

A

Hydrophobicity (or lipophilicity)

40
Q
  • hates water
  • lipid-loving
A

hydrophobic

41
Q

non-polar

A

lipids

42
Q

ability of substance to rotate plane polarized light.

A

Optical Activity

42
Q

measure of how much the speed of light bends or reduced inside a medium

A

Refractive Index

43
Q

include peripheral neuropathy, constipation, fatigue, and sedation.

A

Thalidomide toxicity

43
Q

If a compound rotates plane polarized light in the clockwise (+) direction, it is said to be ____________

A

dextrorotatory

44
Q

the presence of two or more variant forms of a specific DNA sequence that can occur among different individuals or populations.

A

Polymorphism

45
Q

if it rotates light in the counterclockwise (-) direction it is ____________

A

levorotatory

46
Q

failure to calibrate

A

Instrumentation Errors

46
Q

may be defined as a deviation from the absolute value or from the true average of a large number of results

A

Errors

47
Q

affects absorption

A

pH and Ionization

48
Q

3 TYPES OF DETERMINATE ERROR

A
  • Instrumentation Errors
  • Method Errors
  • Personal Errors
48
Q

degredation of parts

A

Instrumentation Errors

49
Q

TYPE OF ERRORS

A
  • Determinate Errors
  • Indeterminate Errors
  • Pseudo-accidental or Variable Determinate Errors
50
Q

errors due to non-ideal physical or chemical behavior

A

Method Errors

50
Q

power fluctuation

A

Instrumentation Errors

51
Q

flaws introduced by the observer

A

Personal Errors

52
Q

errors that can be measured

A

DETERMINATE ERROR

53
Q

usually detectable and can be corrected

A

DETERMINATE ERROR

54
Q

arises from the design of experiment

A

DETERMINATE ERROR

55
Q

error by chance/ accidental in nature

A

INDETERMINATE ERROR

56
Q

limitations of reading balances,
scales such as rulers or dials, and
electrical “noise” in instruments.

A

INDETERMINATE ERROR

57
Q

They arise from random fluctuation in
temperature or other external factors,
changes in pH

A

PSEUDO-ACCIDENTAL/
VARIABLE DETERMINATE

57
Q

environmental factors

A

PSEUDO-ACCIDENTAL/
VARIABLE DETERMINATE

58
Q

same production

A

Repeatability

58
Q

reproducibility and repeatability

A

PRECISION AND ACCURACY

59
Q

2 Types of Precision

A
  • Repeatability
  • Reproducibility
60
Q

the precision when a single analyst completes the analysis in a single session using the same solutions, equipment, and instrumentation.

A

Repeatability

61
Q

the precision under any other set of conditions, including between analysts,
or between laboratory sessions for a single analyst.

A

Reproducibility

62
Q
  • different time
  • same day, different analyst
A

Reproducibility

Phy Pharm LEC (4 decks)

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