Pregnancy dermatoses Flashcards
1
Q
What are the 4 pruritic entities of pregnancy?
A
- Pemphigoid gestatationis
- polymorphic eruption of pregnancy
- prurigo of pregnancy
- cholestasis of pregnancy
2
Q
What is the pathogenesis of pemphigoid gestationis?
A
- anti basemennt membrane zone serum facro:
- C3 deposition along the dermal-epidermal junction.
- post patients have antibodies TO BPAG2(180)
3
Q
What are the clinical features of pemphigoid gestationis?
A
- classically presents during late pregnancy
- abrutp intesely pruritic urticarial lesions on the runk
- pemphigoid like erupsion sparing face,mucous membranes, palms and sole.
some patients may have spontaneous resolution during the later part of gestation only to flare.
- the symptoms may “skip pregnancies” in 5% of patients.
- new borns may be affected up to 10% of the time but the disease is mild- self limited.
4
Q
What effects does pemphigus gestationis have on the newborn?
A
- increased risk of prematurity
- tendency for small-for-gesational-age in neonates.
5
Q
What are the differential diagnosese of pemphigoid gestationis?
A
- PUPP
- allergic contact dermatitis
- drug eruptions
6
Q
what is the treatment of pemphigoid gestationis?
A
- 5mg/kg with the risk of lower birth weight infancts and placental calicifications.
- alternatives including dapsone, doxyclicin/minocyline +/- nicotinomide, cyclosorine).
7
Q
What patients is PUPP usually seen in?
A
- primiparous women
- rapid and excessive weight gain
- multiple-gestation
8
Q
What are the clinical features of pregnancy?
A
- lesions start during the second or third trimester with discrete papules on extensor sufaces. Lesions may or many not be follicular.
9
Q
What are the clinical features of autoimmune progesterone dermatitis?
A
- recurrent cyclical flares of dermatitis –> corresponds to the luteal phase of the menstrual cycle.
- lesions can look like urticaria to papulovesicles to erythema multiforme-like
10
Q
What are some of the phsyiologic changes of pregnancy
A
see page 401 of bolognia
