41- Autoantibodoes encountered in patients with autoimmune connective tissue disease Flashcards
1
Q
Which autoantibodies will be positive in systemic lupus erythematousus
A
-dsDNA - LE nephritis and monitoring the activity of SLE
-Sm
rRNP - neuropsychiatricLE
Anti Ro and Anti La in subacute cutaneous lupus erythemaotusus
2
Q
which antibodies will be elevated in inflammatory dermatomyopathy?
A
- dermatomyositis:
- p155
- Mi2
Jo1 - amyopathic dermatomyositis: Se, 155 kDa
- skin disease Mi-2
3
Q
what drugs can trigger a positive ANA and/or drug-induced SLE syndrome?
A
- procainamide, hydralazine, isoniazid, chlorpromazine, phenytoin,methyldopa.
4
Q
which autoantibody will be elevated in mixed connective tissue disease
A
U1RNP
5
Q
what are the most common IF patterns in ANA seen with systemic sclerosis?
A
- ANA speckled, nucleolar, centromere pattern.
6
Q
which autoantibodies are associated with systemic sclerosis and morphoea?
A
- ANA (positive in 95% of systemic sclerosis)
- centromere (CENP-B)
- DNA topoisomerase I
DNA polymerase III
7
Q
which autoantibodies are elevated in rhematoid arthritis and Sjogren syndrome?
A
Rhematoid arthritis:
- RF
- anti CCP
Sjogrens:
Alpha-fodrin
-Ro
- La
