Pregnancy Complications Flashcards
If performing abortion in 1st trimester what can be given PO to complete abortion? (2)
- what is time frame for medical abortion w/pill?
- what lab value required to do this method
- dosing (days) for each?
What ABX ppx given or this type of abortion/length?
- 1st T Ab –> Mifepristone (Mifeprex) + Misoprostol (Cytotec)
- can be done up 9 wks gestation
- must have Hgb of > 10
day 1 = mifepristone (200-600 mg)
day 2-3 = misoprostol (400-800 mcg)
Ppx = doxycycline for 7 days
note: at PG they give 2 doses of Cytotec
1st T Medical Ab
- What type of drug is Mifepristone/what does it cause?
- What about Misoprostol?
1st T Ab
- Mifepristone
- progesterone antag –> decr endometrial growth, cant maintain preg
Misoprostol (Cytotec)
- PGE1 analog –> causes uterine contractions–> expel fetus
1st T Medical Ab:
2 main S/Es a/w Medical Ab in 1st T
1st T Ab: 2 main S/Es
- abd pain/cramping
- bleeding
1st T Medical Ab w/injection
What is given for medical abortion injection occurring in 1st trimester? (2) - rarely used but more commonly used for _____ preg
1st T Ab w/injection
IM Methotrexate + Misoprostol (cytotect)
- rarely used but for Ab more commonly used for ectopic preg
1st T Ab f/u: Medical
1+2. What are 2 options that can confirm the medical Ab is complete 2 wks later
- What is also given to Rh- mothers
1st T Ab f/u: 2 things confirm medical Ab is complete 2 wks later
- US
- bhCG level
- give Rh- moms Rhogam
1st T Ab: Surgical
- 2 options
- What is given to cause cervical dilation? when?
Next step?
1st T Ab: Surgical
- 2 options
- D+C
- MVA (Manual Vacuum Aspiration) - For D+C –> misoprostol to cause cervical dilation at 13+ wks –> suction aspiration
2nd T Ab: Surgical
Two types of surgical abortion performed in the 2nd trimester?
Which one can be performed later in preg? when?
Which has higher complication rate (so rarely done unless mom at risk)?
What do they both require prior the surgery? What is it made of?
- D & E (dilation & evacuation)
- D & X (dilation & extraction)
- done later –> 21+ wks
- higher complication rate (rarely done)
BOTH: require input of laminaria into vagina–> dilate cervix
- sterile, compressed seaweed
6 complications of ALL surgical abortions
- Incomplete abortion
- Uterine perforation
- Cervical trauma/insuffic
- Infection (endometritis)
- Hemorrhage/Bleeding
- Adhesions (Asherman’s Syn)
Note: adhesions only affect ability to stay preg
Other Option for 2nd T Ab
uses cervical ripening agents, aminotomy, high dose IV oxytocin (pitocin)
S/Es = retained placenta, uterine rupture, hemorrhage, infxn
Cons: longer process (days)
Pros: may have intact fetus –> postmortem eval
Other Option for 2nd T Ab = IOL
uses cervical ripening agents, aminotomy, high dose IV oxytocin (pitocin)
S/Es = retained placenta, uterine rupture, hemorrhage, infxn
Cons: longer process (days)
Pros: may have intact fetus –> postmortem eval
What is the definition of SAB (spontaneous abortion)/ Miscarriage
- what is it often d/t
loss of preg < 20 wks gestation
often d/t chrom abnormalities
4 major RFs for SAB?
- AMA
- previous SAB
- Smoking
- Meds/Substances
- EtOH, cocaine, NSAIDs
NSAIDs = PG inhib
Complete abortion:
- how does cervical os look?
- POC expelled?
- what seen on sono?
- Tx?
Complete abortion:
- cervical os = CLOSED
- POC EXPELLED
- Sono –> empty uterus
- Tx = follow bhCG levels
INcomplete abortion:
- definition
- how does cervical os look?
- POC expelled?
- what seen on sono?
- Tx?
INcomplete abortion:
- incomplete = misscarriage in process
- cervical os = OPEN/DILATED
- Some POC retained/visible
- Sono –> no IUP, debris in uterine cavity
- Tx = intervention to complete the abortion
Missed abortion:
- definition/bhCG levels
- how does cervical os look?
- POC expelled?
- what seen on sono?
- Tx?
only difference seen w/blighted ovum on sono?
missed abortion
- NON-VIABLE preg (bhCG decreasing), hasnt been expelled yet
- Cervical os = closed
- No POC expelled
- sono–> no cardiac activity
Tx: give something to expel POC
blight ovum
- large GS + yolk sac but NO EMBRYO
What is the only type of abortion that may be viable/continue
Threatened abortion
Threatened abortion
- cervical os?
- what is seen on sono that is different from all other abortions
- sxs?
- tx?
Threatened abortion
- cervical os = closed (preg still may be viable)
- Sono - VIABLE IUP (heartbeat)
- Sx = spotting
- Tx = expectantly manage
Inevitable Ab
- how does cervical os look?
- POC expelled?
- what seen on sono but why cant preg continue?
- Tx?
Inevitable Ab
- os = open
- POC not expelled
- sono = viable IUP but preg
cant continue b/c os is open - Tx = expectantly or surgical procedure to expel fetus
23 y/o F underwent D+C 3 days ago. C/o continued vaginal bleeding, lower abd cramping, and recently noted fever/chills x1 day. PE - temp = 102, BP = 90/48, HR = 120. Abd/Pelvic exam reveals open os, uterine tenderness and CMT. Labs show elevated WBCs.
Dx?
Tx - what 2 ABXs best and what procedure should be done 4 hrs after ABX start
Dx = Septic Abortion
Tx = Broad spectrum ABX w/ Gentamicin + Clindamycin
- after 4 hrs –> D+C to remove POC
note: also give IVF for HoTN
Septic Abortion
- what type of infxn
- what type of vaginal d/c is it a/w it
- What is tx if refractory to ABX and D+C
Septic Abortion
- ascending infxn
- foul smelling, purulent vaginal d/c
- refractory to ABX and D+C = Hysterectomy
Confirming preg w/lab tests:
- Which type of pregnancy test is qualitative?
- Which type of pregnancy test is quantitative?
- what levels are definitive (+)?
- how do the levels change in a norm preg
Other method than lab testing to confirm preg?
Confirming preg w/lab tests:
- urine pregnancy test (UPT) = qualitative
- B-hCG = quantitative (blood test)
- > 25 = definitive confirmation of preg
- double every 2-3 days in norm preg
Other method to conifrm preg = TVUS
TVUS & preg confirmation:
- What should be present at 4-5 wks?
- at 5 wks
- at 6 wks
- at 6.5 wks
- At what level of b-hCG is normal IUP visualized?
- will bhCG double q48hrs w/ectopic
TVUS & preg confirmation:
- 4-5 wks –> gestational sac
- 5 wks –> yolk sac
- 6 wk –> fetal pole
- 6.5 wks –> FHM (fetal heart motion)
- norm IUP visualized at b-hCG > 1500-2000
- No, bhCG wont double q48 hrs w/ectopic preg
MC site of ectopic pregnancy
Ampulla
Pt pts w/ unilateral pelvic/abd pain, amenorrhea, and vaginal bleeding. Pt has h/o endometriosis, PID and smoking. She currently uses IUD for contraception. On PE pt has an adenexal mass and CMT w/mild uterine enlargement. bhCG level is 2500 but no intrauterine gestational sac seen on US.
Dx?
Tx?
Dx = Ectopic Pregnancy
Tx = MTX
Main Sx a/w Atypical presentation of Ectopic preg?
What does this cause?
Type of Ecotopic?
Atypical presentation = shoulder pain –> fluid irritating diaphargm –> peritonitis
Ruptured Ectopic
Pt comes in to ED and you find out she has an ectopic pregnancy. She is cool, tachycardic, HoTNsive, and has severe abd pain, N/V and is dizzy. On PE you find free fluid in her pelvis.
What type of ecotopic pregancy is this?
Ruptured Ecotopic Pregnancy
How to distinguish ectopic preg from miscarriage?
heavy bleeding (miscarriage) –> declining b hCG
Medical Tx of Ecotopic pregnancy w/MTX:
- what days do you check b hCG levels
- how often do you follow them til?
- what do you do if this method fails (2 options)
Medical Tx of Ecotopic pregnancy w/MTX:
- check b hCG levels on Day 1, 4, 7
- follow b hCG til < 5
- MTX fails –> 2nd dose MTX or surgery
Surgical Tx of Ectopic Preg
2 surgical options (Laparoscopic)
How are they different?
Which is 1st line Tx?
which is not good for pts who want to get preg later on?
which type must you follow bhCG levels < 5
Laparoscopic
- Salpingectomy = 1st line
- remove fallopian tube
- not good if want to get preg later on - Salpingostomy
- just remove pregnancy –> must follow bhCG
If you cant definitively determine if ectopic or rule it out then what 2 things should be repeated/when?
- Repeat b hCG in 48hrs
2. Repeat TVUS - once b hCG above discriminatory zone
Inability to maintain pregnancy d/t premature dilation
MC in what trimester
Incompentent Cervix/ Cervical Insuffic
Inability to maintain pregnancy d/t premature dilation
MC in 2nd Trimester
biggest RF for Incompentent Cervix/ Cervical Insuffic
biggest RF for Incompentent Cervix/ Cervical Insuffic
h/o cervical trauma/surgery
cone bx, cervical lac
G2P1 Pt who is 20 wks gestation presents c/o vaginal bleeding and d/c but no pain. on PE you notice dilated cervix that is somewhat effaced. Pt had h/o cervical lac w/ prior delivery and had cone Bx done to r/o cervical CA.
Dx?
Tx?
Dx = Incompentent Cervix/ Cervical Insuffic
Tx = Cerclage