Pregnancy Flashcards
1
Q
What happens to CD4 counts during pregnancy?
A
Typically drop
2
Q
Why is there an increased susceptibility to infectious diseases during pregnancy?
A
Shift from cell mediated to humoral immunity
3
Q
Which opportunistic infections can pass via vertical transmission?
A
Mycobacterium tuberculosis, cryptococcal infection, CMV, PCP, toxoplasmosis
4
Q
How to manage HIV2 in pregnancy?
A
Can’t use NNRTIs
Darunavir/r BD
Infant PEP - AZT/3TC + RAL
Discuss!!!
5
Q
Dolphin study
A
Median time to suppression was 4 weeks in DTG compared for 12 weeks with EFV
Hence if high VL late presentation in pregnancy to have INI DTG bd or ral BD
6
Q
PROMISE trial
A
Women received CART throughout breastfeeding - 0.3% at 6 months, 0.6% at 12 months
