Antiretroviral Drugs

Question 1

How does Abacavir affect CV risk?

Answer 1

Hypothesises increased platelet aggregation

Question 2

ARV with known Potential cause renal stone

Answer 2

Atazanavir

Question 3

Potential cause protein leak from kidneys

Answer 3

Tenofovir - proximal tubule

Question 4

Factors associated with CAB/RPV failure

Answer 4

Subtype A
BMI >30
Previous failure to non nucleoside based regimen

Had to have at least 2 of these to fail

Question 5

Fostemsavir

Answer 5

Oral taken BD
In people who have failed
Attachment inhibitor

Question 6

Ibilizumab

Answer 6

Available for multi drug resistant HIV
Postattachment inhibitor - blocks viral entry into CD4 cells
Iv infusion every 2 weeks plus optimised background regimen of oral therapy

Question 7

Lenacapavir

Answer 7

Capsid inhibitor

Question 8

Drugs affected by increased gastric PH

Answer 8

Atazanavir
Rilpivirine

Question 9

Drugs affected by chelating compounds
Eg mg, ca, iron

Answer 9

Integrate inhibitors decreased

Question 10

How does drv/r affect carbamazepine?

Answer 10

Increases carbamazepine AUC by 45% so advised to monitor carbamazepine levels and adjust dose accordingly

Question 11

Ritonavir with vinblastine

Answer 11

Increased neutropenia risk

Question 12

Raltegravir in pep DDI

Answer 12

At least 4 hrs apart from antacids, iron supplements, multivits