Precision Medicine

Question 1

Traditional medicine interventions are assessed based on the average response of a group of people. The …. approach involves collection of extensive data on genetics, environment, and lifestyle to tailor preventions and interventions to the individual.

Answer 1

precision

Question 2

… sequencing is performed by building a genomic library, conducting massively parallel sequencing, and aligning the reads to a reference genome

Answer 2

whole genome

Question 3

using genomic data (one gene or many genes) from a patient to optimize drug treatment; maximizing efficiency and minimizing harmful side effects

Answer 3

pharmacogenomics - refers to using many genes

pharmacogenetics - refers to using one gene

Question 4

… factors can influence the rate of metabolism or the off-target effects of a drug
* some people may metabolize drug faster or slower than others - certain drug regimes need tailored approaches based upon this so that too much or too little drug is not given

Answer 4

genetic

Question 5

.. can be performed by cutting the genome at a specific site to allow repair with a different sequence

Answer 5

genome editing

• Efficient genome editing requires a delivery system, a DNA fragment to serve as a template for the change, and machinery to cut the genome at the site of interes

Question 6

… technology is currently the leading approach to genome editing

Answer 6

CRISPR

• Cas9 protein can cut DNA
• guide RNA directs cas9 to region to cut

problems:
specificity & delivery