Pre-NAPLEX

Question 1

Which of the following medications may cause a decrease in metabolism of simastatin?

• Paxil
• Aspirin
• Diltiazem
• Doxazosin
• Spironolactone

Answer 1

Diltiazem
________________________
Simvastatin is metabolized by CYP3A4.
Diltiazem inhibits CYP3A4.

Question 2

How many hours should a nitroglycerin patch remain on a patient?

Answer 2

12 hours

Question 3

Which of the following beta blockers would be appropriate to initiate for unstable angina if symptoms don’t respond to NG?

• Acebutolol
• Pindolol
• Metoprolol

Answer 3

Metoprolol
________________________
Cardioselective beta blockers are preferred for unstable angina. Beta blockers with intrinsic sympathomimetic activity (acebutolol) should be avoided in heart failure patients.
Preferred agents: Metoprolol, Atenolol

Question 4

Which of the following references would provide the best information regarding proper storage of medications?

• Drug Topics Redbook
• Applied Therapeutics
• American Drug Index
• Approved Drug Products
• Physician’s Desk Referece

Answer 4

Physician’s Desk Reference
________________________
PDR - a collection of product package inserts.

Question 5

What information is provided by the following reference - Drug Topics: Red Book

Answer 5

The Red Book is a useful resource to determine product presentations (dosage form, strength, package size) and availability.

Question 6

What information is provided by the FDA Orange Book?

Answer 6

Generic - brand equivalence

Question 7

What information is provided by the FDA Purple Book?

Answer 7

Lists biological products, including any biosimilar and interchangeable biological products.

Question 8

What online resources provide access to individual product package inserts?

Answer 8

NLM: Dailymed

Physician’s Desk Reference (PDR)

Question 9

Name the generic, class, and use of Foradil.

Answer 9

• Foradil INHALER
• (formoterol fumarate aerosolized powder)
• LABA - long-acting beta agonist

Question 10

When prescribed for asthma, is Foradil dosed PRN or on a scheduled basis?

Answer 10

Both.
_______________________
Foradil inhaler can be used for:
-Maintenance: in conjunction with an inhaled corticosteroid - given every 12 hours, or
-To treat exercised-induced symptoms, in which case is must be taken at least 15 mins prior to exercise, no more than once every 12 hours.

Question 11

An adverse reaction to which medication would most likely necessitate the addition of Mycelex Troches?

• Foradil
• Claritin
• Yasmin
• Proventil
• Pulmicort

Answer 11

Pulmicort
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Mycelex troches: clotrimazole 
Pulmicort: budesonide inhaler
  - Corticosteroid --> oral thrush

Question 12

What is the generic name and dosage form of Acular?

Answer 12

Ketorolac ophthalmic drop

Question 13

What is the generic name for Zyvox?

Answer 13

Linezolid

Question 14

What are the monitoring parameters for Zivox?

Answer 14

Weekly CBC, visual function