Pre-med drugs Flashcards
MOA of anticholinergics
Class of drug that inhibits the paraysmpathetic nervous system. It antagonizes the muscarinic acetylcholine receptors.
Anticholinergic common drugs
Atropine, Glycopyrrolate
MOA of alpha2 agonists
competitive agonist of alpha2 adrenergic receptors
A2 adrenergic receptor function
…
Effects of A2 agonists (major effects)
Sedation, analgesia, reduced stress response, muscle relaxation, strong vasoconstriction, mild resp. depression
A2 agonist drugs
Xylazine, Dexmedetomidine, Medetomidine, detomidine, Romifidine
A2 antagonists (reversals)
Atipamezole, Yohimbine, Tolazoline
Phenothiazines MOA
Antagonists of multiple receptors (Dopamine, serotonin, alpha1, histamine)
Phenothiazines major effects
sedation, antiemetic, mild respiratory depression, vasodilation
Phenothiazine drugs
Acepromazine
Butyrophenones MOA
similar to phenothiazine??
Butyrophenones major effects
sedative, vasodilation, antiemetic
butyrophenones drug
Droperidol, azeperone (stresnil)
Benzodiazepines MOA
GABA receptor agonists.
GABA receptor function
The main inhibitory neurotransmitter in the CNS
Benzodiazepine major effects
sedative, anticonvulsant, muscle relaxation
Benzodiazepines agonist drugs
Diazepam, Midazolam, Zolazepam (Zoletil or Telazol)
Benzodiazepine antagonists (reversal)
Flumazenil, Sarmazenil
Opioid receptors
mu (strong analgesia, resp depression, dependency), kappa (weaker analgesia), sigma (weak analgesia human)
Opioids general major effects
Analgesia, MAC sparing, dysphoria, vomiting
Full mu agonists (drugs)
Morphine, hydromorphone, oxymorphone, Methadone, Fentanyl, Remifentanil
Mixed opioid antag/anogists
Butrophanol (mu antagonist, kappa agonist)
partial or weak mu agonists
Buprenorphine (partial), tramadol (comes from metabolite)
Opioid antagonists
Naloxone, Naltrexone