Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PCOL 2 > PRE-FINAL 1 > Flashcards

PRE-FINAL 1 Flashcards

Anticoagulants and Coagulants

1
Q

Is animportantprocess that prevents excessive bleeding when a blood vessel is injured.

A

Bloodclotting orCoagulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

(a type of blood cell) and proteinsinyour plasma (the liquid part of blood) work together to stopthebleeding by forming a clot overtheinjury.

A

Platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the chemistry of Heparin?

A

Sulfated glycosaminoglycan

a. unfractionated
b. low –MW

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the chemistry of Warfarin?

A

Coumarin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Route of administration: Parenteral (IV or SC) Not IM-produce hematoma

A

Heparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Route of administration: Oral, IV

A

Warfarin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the route of administration of Heparin?

A

Parenteral (IV or SC)
Not IM-produce hematoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the route of administration of Warfarin?

A

Oral, IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the uses of Heparin?

A

Post MI, Prevention of DVT and PE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the uses of Warfarin?

A

Prevention of DVT and PE
Atrial fibrillation
Artificial heart valves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the mechanism of Heparin?

A

Activates antithrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the mechanism of Warfarin?

A

Inhibits Vit. K synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the side effects of Heparin?

A

Bleeding, Allergy, Thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the side effects of Warfarin?

A

Bleeding and Teratogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the monitoring in Heparin?

A

Activated partial thromboplastin time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the monitoring in Warfarin?

A

Prothrombin time (expressed as INR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the antidote of Heparin?

A

Protamine sulfate (1mg/100 units)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the antidote of Warfarin?

A

Vitamin K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the MW of Unfractionated Heparin?

A

MW = 5,000-30,000 Daltons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the drugs under Low molecular weight heparins (LMWH)?

A

Enoxaparin, dalteparin, tinzaparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

It has longer half life and less bleeding, routine aPTT unnecessary

A

Low molecular weight heparins (LMWH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

A mixture of sulfated glycosaminoglycosan

A

Danaparoid Na

22
Q

What are the mixture of sulfated glycosaminoglycosan?

A

Heparin, Dermatan, Chondroitin

23
Q

Is a preferred drug given to a pregnant woman, it does not cross the placenta.

A

Heparin

24
Q

What are the Coumarin derivatives?

A

Warfarin Sodium and Dicumarol

25
Q

It dissolves clot and converts plasminogen—-plasmin (fibrinolytic)

A

Thrombolytics (enzymes)

26
Q

A protein from streptococci

A

Streptokinase

27
Q

What are the side effects of Streptokinase?

A

Hemorrhage and Allergy

28
Q

Only binds to plasminogen bound to fibrin.

A

Tissue plasminogen activators

29
Q

What is the side effect of Tissue plasminogen activators?

A

Hemorrhage

30
Q

Inhibits platelet aggregation and prolongs bleeding time.

A

Antiplatelets

31
Q

What are the uses of Antiplatelets?

A

Prevention of MI, stroke

32
Q

Prevents thromboxane synthesis by inhibiting cyclooxygenase and prevention of MI, stroke

A

Aspirin

33
Q

What are the side effects of Aspirin?

A

GI ulcer and Bleeding

34
Q

Blocks ADP(adenosine diphosphate) receptor in the platelet cell membrane and prevention of MI, stroke.

A

Thienopyridines

35
Q

What are the drugs under Thienopyridines?

A

Clopidogrel and Ticlopidine

36
Q

What are the side effects of Clopidogrel?

A

Nausea, Vomiting, Diarrhea, Hemorrhage

37
Q

What is the side effect of Ticlopidine?

A

Neutropenia

38
Q

Prevention of stroke and MI; nuclear cardiac stress testing
Inhibits adenosine reuptake—-decrease platelet aggregation
Inhibits phosphodiesterase—–Inc. cGMP—vasodilation

A

Dipyridamole

39
Q

For patients undergoing percutaneous coronary intervention (angioplasty) and to decrease the incidence of hemorrhage

A

Glycoprotein IIb/ IIIa inhibitors

40
Q

What are the drugs under Glycoprotein IIb/ IIIa inhibitors?

A

Abciximab, Eptifibatide, Tirofiban

41
Q

What is the side effect of Glycoprotein IIb/ IIIa inhibitors?

A

Bleeding

42
Q

What falls under the category of Thrombolytics (enzymes)?

A

Streptokinase and Tissue plasminogen activators

43
Q

What are the drugs under Antiplatelets?

A

Aspirin, Thienopyridines, Dipyridamole Glycoprotein IIb/ IIIa inhibitors

44
Q

Identify if the vitamin is fat soluble or water soluble: Vitamin K1 (phytonadione)

A

Fat Soluble

45
Q

Identify if the vitamin is fat soluble or water soluble: Vitamin K3 (menadione)

A

Fat Soluble

46
Q

Identify if the vitamin is fat soluble or water soluble: Vitamin K4 (menadiol)

A

Water Soluble

47
Q

What is the MOA of Vitamin K and its synthetic derivatives?

A

Promotes the synthesis of Factors II, VII ,IX and XI

48
Q

Identify the name of this factor: Factor II

A

Prothrombin

49
Q

Identify the name of this factor: Factor VII

A

Proconvertin

50
Q

Identify the name of this factor: Factor IX

A

Plasma thromboplastin component

51
Q

Identify the name of this factor: Factor XI

A

Stuart factor

52
Q

Is the drug of choice for the treatment of anticoagulant overdose and HDN (hemorrhagic disease of newborn) because it has the same degree of activity with the naturally occurring vitamin and have better margin of safety.

A

Vitamin K1

53
Q
A

PCOL 2 (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions