pre eclampsia

Question 1

what is pre-eclampsia

Answer 1

hypertension and proteinuria

Question 2

what is eclampsia

Answer 2

hypertension + proteinuria + seizure

Question 3

symptoms of pre-eclampsia

Answer 3

generally asymptomatic

blurring of vision
headache
oedema
slow growth of baby

Question 4

risk factors for pre-eclampsia

Answer 4

first time pregnancy
multiple gestations
>35 years old
pre-existing HTN/ DM
obesity
previous pre-eclampsia or FHx

Question 5

what medication is given to those with risk factors for pre-eclampsia

Answer 5

150 mg aspirin

Question 6

what is the suspected pathophysiology of pre-eclampsia

Answer 6

placenta is hypoperfused due to abnormal development
it releases pro-inflammatory proteins into maternal circulation
leading to dysfunctional vessel endothelium causing:
vasoconstriction
salt retention
thrombi formation - haemolysis
increased vascular permeability

Question 7

what are complications of pre-eclampsia

Answer 7

seizure
haemorrhagic stroke
placental abruption

Question 8

management of pre-eclampsia

Answer 8

delivery of baby
BP control (labetalol, nifedipine)
IV magnesium sulphate
fluid control