Pre-eclampsia Flashcards

1
Q

What happens to BP in normal pregnancy?

A

There is a reduction in BP during pregnancy due to physiological changes (increased cardiac output due to increased HR and SV paired with reduced vascular resistance)

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2
Q

Define ‘Chronic Hypertension’ in pregnancy

A

Raised BP before pregnancy or diagnosed hypertension before 20/40

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3
Q

Define ‘Gestational Hypertension’

A

Raised BP after 20/40 with no systemic features

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4
Q

What is the Pre-Eclampsia (PET) triad?

A
  1. HTN (140/90)
  2. Oedema
  3. Proteinuria
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5
Q

What is the incidence of PET?

A

3-5% of pregnancies

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6
Q

List the 5 signs and symptoms of PET

A
  1. Headache
  2. Visual disturbance
  3. RUQ pain (hepatic ischaemia)
  4. Reduced urine output
  5. Lower abdominal pain (placental abruption)
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7
Q

What 4 signs might you see on clinical examination of a patient with PET?

A
  1. Pulmonary oedema signs (orthopnoea, dull to percuss, no breath sounds)
  2. Hepatic tenderness (RUQ)
  3. Peripheral oedema
  4. Hyperreflexia
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8
Q

Name at least 2 maternal complications from PET

A
  1. Eclampsia (seizure)
  2. Renal failure
  3. Pulmonary oedema
  4. Stroke
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9
Q

List at least 2 foetal complications when a mother has PET

A
  1. IUGR
  2. Placental abruption
  3. Stillbirth
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10
Q

List the 8 risk factors for PET

A
  1. Previous PET
  2. Primigravida
  3. FHx of PET
  4. Pre-existing HTN
  5. Diabetic
  6. Obesity (BMI >30)
  7. Renal disease
  8. Connective tissue disorder (SLE, EDS)
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11
Q

What is it always important to consider in patients who develop PET?

A

Is the patient bleeding? Could this be placental abruption?

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12
Q

What investigations should we carry out for the maternal diagnosis?

A
  • FBC - anaemia? Bleeding?
  • U&E - renal failure? Systemic problems?
  • LFT’s - Hepatic involvement, any ischaemia?
  • Urea/creatinine ratio
  • Urine dipstick - proteins?
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13
Q

What investigations do we need to carry out to assess foetal wellbeing?

A
  1. USS - growth?

2. CTG - foetal HR

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14
Q

What is the ultimate way to control PET?

A

Deliver the baby safely

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15
Q

What symptoms indicate an immediate delivery of the baby in PET?

A
  1. Progressive organ dysfunction of mum
  2. Inability to control BP with medication
  3. CTG pathological/worrying
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16
Q

What orchestrates this illness?

A

Placental dysfunction

17
Q

How do we treat mothers with PET?

A
  1. BP control - Keep the systolic <160 with labetolol, nifedipine or hydralazine to prevent cerebral bleeding
  2. Fluid balance - restrict fluid due to oedema
  3. Prevention of eclampsia - Magnesium sulfate infusion
18
Q

What is HELLP syndrome?

A

Haemolysis - low Hb
Elevated Liver enzymes - hepatic damage
Low Platelets

19
Q

What medication is given IV to patients with pre-eclampsia to prevent pregnant women becoming eclamptic?

A

Magnesium sulfate