Ectopic pregnancy Flashcards

1
Q

What is an ectopic pregnancy?

A

A pregnancy that implants outside the uterus.

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2
Q

What percentage of pregnancies in the UK are ectopic?

A

1%

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3
Q

What is the most common site of an ectopic pregnancy?

A

Fallopian/uterine tube

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4
Q

Where can an ectopic pregnancy implant?

A
Fallopian tube
ovary
Cornual (interstitium of the FT)
Caesarean section scar
Heterotopic pregnancy (uterine and ectopic pregnancy)
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5
Q

List 6 risk factors for ectopic pregnancy

A
  1. Previous PID
  2. Smoking
  3. Prior tubal surgery
  4. Previous STI (chlamydia in particular)
  5. Hx of infertility
  6. IUD/coil
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6
Q

What are common symptoms of ectopic pregnancy?

A

Pain (could be mild or severe, usually unilateral)
Shoulder tip pain (referred from diaphragmatic irritation from blood in the peritoneum)
Rectal pain
Diarrhoea
PV bleeding
Collapse, dizzy, syncope (hypovolaemia)

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7
Q

What would you look for on speculum examination?

A

cervical excitation or adnexal tenderness

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8
Q

What could be found on abdominal examination?

A

Guarding, rebound tenderness and distention (signs of pregnancy and peritonitis)

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9
Q

When does an ectopic pregnancy usually occur and why?

A

Between 5 and 7 weeks gestation as this is when the foetus grows to a size big enough to cause pain in the fallopian tubes and/or rupture

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10
Q

What are the 3 options for management of ectopic pregnancy?

A
  1. Surgical management
  2. Medical management
  3. Conservative management
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11
Q

What is a laparoscopic salpingectomy?

A

Removal of the fallopian tube via laparoscopic surgery

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12
Q

What is a laparoscopic salpingotomy?

A

Removal of the section of the fallopian tube with the ectopic pregnancy in. This can leave behind a damaged fallopian tube.

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13
Q

What medication is used for medical management of an ectopic pregnancy?

A

Methotrexate

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14
Q

What is the recurrence rate of an ectopic pregnancy in women who have had a salpingectomy?

A

10%

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15
Q

What is a common sign seen on USS of an ectopic pregnancy?

A

The donut sign

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16
Q

How long must a patient wait to try for another pregnancy after medical management of an ectopic pregnancy?

A

3/12

17
Q

How do we calculate methotrexate dosage?

A

50mg/m^2 using the DeBois surface area calculator

18
Q

When do we follow-up a patient after medical management?

A

At 4/7 and 7/7 post treatment.

19
Q

What would you do if the hCG was still rising 4/7 post treatment?

A

Reassess at 7/7 post-treatment, if the hCG is still rising at this point, further treatment is required.

20
Q

When can you give a repeat dose of methotrextate?

A

7 days after the first dose

21
Q

As a percentage, how much should hCG reduce between day 4 and day 7 post methotrexate dose?

A

15%

22
Q

What is the mechanism of action of methotrexate?

A

Folate antagonist, therefore prevents rapidly dividing cells from doing so.