Pralidoxime Chloride (2PAM) Flashcards
Pralidoxime Chloride (2PAM) Class
Cholinesterase reactivator
Pralidoxime Chloride (2PAM) Mechanism of Action
Reactivation of cholinesterase to effectively act as an antidote to organophosphate pesticide poisoning. This action allows for destruction of accumulated acetylcholine at the neuromuscular junction.
Pralidoxime Chloride (2PAM) Indications
As an antidote in the treatment of poisoning by organophosphate pesticides and chemicals. In the prehospital arena, is used when atropine is or has become ineffective in the management of organophosphate poisoning.
Pralidoxime Chloride (2PAM) Contraindications
Use in caution with patients who have reduced renal function; patients myasthenia gravis
Pralidoxime Chloride (2PAM) Adverse Reactions
dizziness, blurred vision, diplopia, headache, drowsiness, nausea, tachycardia, hyperventilation, muscular weakness, excitement, and maic behavior.
Pralidoxime Chloride (2PAM) Drug Interactions
No direct drug interactions
Pralidoxime Chloride (2PAM) Adult Dosage
Adult: Initial dose is 1 – 2 g as an IV infusion with 100 mL saline over 15 – 30 minutes.
Pralidoxime Chloride (2PAM) Pediatric Dosage
Pediatric: 20 – 40 mg/kg IV infusion over 15 – 30 minutes.
Pralidoxime Chloride (2PAM) Repeat Dosage
Doses may be repeated every hour if muscle weakness persists.
Pralidoxime Chloride (2PAM) Onset
1 minute
Pralidoxime Chloride (2PAM) Peak Effect
Variable
Pralidoxime Chloride (2PAM) Duration
Variable
Pralidoxime Chloride (2PAM) Special Considerations
Cardiac monitoring should be considered.
