Practice vivas Flashcards

1
Q

Inverted papilloma

A

Differential - mucocele (complete opacification by mucous, with bony expansion 2 to drainage obstruction)
Antrochoanal polyp - arise in maxillary sinus and expand posterior nasal cavity and nasopharynx
SCC, olfactory neuroblastoma, other tumour

Arise most commonly in lateral wall of nasal cavity, in proximity to the maxillary ostium. Often extends into maxillary sinus as expands.

High association with malignancy (degenerate to SCC 15% and others), and tend to recur

T2 and T1+ convuluted cerebriform pattern.

40-60, male prediliction

HSV 6, 11
May calcify

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2
Q

SCC with nodes

A

Look for subtle SCC primary if see nodes

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3
Q

Cervical lymph node groups

A

1 anterior to submandibular
2 jugular, base of skull to hyoid
3 lower hyoid to cricoid, lateral to medial margin of carotid vessels
4 lower hyoid to clavicle, lateral to carotid, anteromedial to SCM and then scalene
5 posterior triangle
6 pre laryngeal, hyoid to manubrium. Anterior to 3 and 4
7 superior mediastinal, between CCAs, to brachiocephalic level
1a submental b submandibular
5a upper, b lower (cricoid)

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4
Q

Fungal sinusitis

A

Allergic fungal - chronic, associated with asthma, expansion and possibly erosion
Centrally hyperdense material
Acute invasive fungal sinusitis - not hyperdense, tend to be immunocompromised or diabetic
Chronic invasive

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5
Q

Parapharyngeal space

A

Parotid and masticator both displace medially (antero and postero respectively)
Carotid space displaces it anteriorly
Retropharyngeal and pharyngeal mucosal space displace it laterally (antero and postero respectively)

Pleomorphic adenoma deep lobe can appear entirely extra parotid. The tumour can also rarely arise from rests in the parapharyngeal space

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6
Q

Parotid gland anatomic pathologies

A

Deep and superficial lobes, separated by facial nerve (retromandibular vein approximate)
Not truely anatomically discrete - important surgically
Most benign tumours are in superficial lobe (though rarely deep also - e.g. pleomorphic adenoma, which when deep can appear entirely extra parotid, or can arise from rests in the parapharyngeal space) while most malignant involve both
Exclusive deep lobe tumours are rare - use parapharyngeal sapce to help localise

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7
Q

Most common malignant parotid gland tumour

A
Mucoepidermoid carcinoma (these most commonly arise in parotid gland also)
Perineural spread (as with adenoid cystic)
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8
Q

Glomus tympanicum paraganglioma

A

The most common middle ear tumour
2nd most common head and neck paraganglioma after carotid body
Other common: cholesteatoma, schwanomma
Female prediliction, <40
Pulsatile tinnitis, otalgia, or conductive hearing loss
Arise from Jacobsen nerve at Cochlear promintory (tympanic branch of glossopharyngeal)
Soft tissue mass lateral to cochlear promontory. May destroy ossicles

(glomus jugulare, glomus vagale, carotid body)

T1 salt and pepper
Surgical excision, endovascular embolisation pre-op may reduce bleeding risk

Vascular red mass on exam, retrotympanic
Differential aberrant carotid, tympanic membrane haemangioma

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9
Q

Middle ear tumour

A
Glomus tympanicum
Schwanomma facial nerve
Cholesteatoma
Cholesterol granuloma
SCC or BCC or external meatus
Head and neck SCC
Parotid gland masses
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10
Q

Petrous apex mass

A
Mets myeloma
Chondroma, chondrosarc
Meningioma
Schwannoma, cholesterol granuloma, cholesteatoma
Apical petrositis
LCH
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11
Q

Clival mass

A

Mets, myeloma, chondrosarc, chordoma

Or intracranial growing into clivus - pituitary macro (can have dural tail), invasive. Meningioma. Craniopharyngioma

Or Naso/pharyngeal growing up - mucocele, SCC, rhabdomyosarc

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12
Q

Papillary thyroid cancer

A

Mets to nodes c.f. follicular where more rare, but often haematogenous
Follicular cancer and adenoma not differentiated on FNA
Microcalc common
Cavitatory nodes
Medullary tends to have calc in primary and secondary sites (nodes)

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13
Q

Intracranial epidermoid

A

Present due to mass effect
Can have aseptic meningitis
3rd most common CP angle mass after meningioma and schwannoma
May be seen in other cisterns, or in skull
Diffusion restricts
Do not enhance
Differential arachnoid, dermoid (fat on CT, midline)), inflammatory cyst (neurocystercicosis), cystic tumour (solid enhancement)

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14
Q

Warthins v Pleomorphic

A

Warthins can be cystic, most common multifocal mass, and doesn’t calcify
Pleomorphic most common mass, may calcify
Warthins tumour only one which favours males. Benign, can excise or follow up with imaging.
Pleomorphics removed because of risk of malignant degeneration (10% at 15 years)

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15
Q

Chordoma

A

Notochord remants
Sacrococcygeal > spheno-occipital > vertebral
Most common primary malignant sacral tumour
Sacrococcygeal ones are more common in men
Intratumoral calc, moderate to marked enhancement
T2 high, may have haemorrhage
Locally aggressive, recurrence common, poor prognosis. Metastasis uncommon.

Physiliferous cells

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16
Q

Chondrosarcoma

A

Paramidline cf. Chordoma which are midline
High T2 and rings and arcs calc
Meningioma has low T2 and craniopharyngioma (papillary) doesn’t calcify (Cf. chondrosarc and chordoma)

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17
Q

Antrochoanal polyp

A

A type of sinonasal polyp
Inflammatory polyp, lined by respiratory epithelium and with inflammatory infiltrate
Arise from maxillary sinus and pass into nasopharynx, expanding
Young adults, sinus symptoms
Maxillary ostium expanded by mass
High T2, with peripheral enhancement

A sinus retention cyst may be indistinguishable from a polyp

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18
Q

JNA

A

Juvenile nasopharyngeal angiofibroma
Benign but highly vascular
Males almost exclusively
Arise in region of sphenopalatine foramen (posterolateral nasal wall)
Surgery with pre-op embolisation
Prominent T2 flow voids (punctate and serpentine) and enhances
Expanded sphenopalatine foramen with bowed posterior wall of maxillary sinus
Grossly Gray-white tan

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19
Q

Basal ganglia calcification

A

Idiopathic
Fahrs
Toxic - CO, lead, chemo/rad
Infectious - TORCH, TB, AIDS, cystercicosis, toxoplasmosis
Metabolic - hypo, pseudo, pseudopseudohyp, hyperparathyroidism, mitochondrial disease - MELAS

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20
Q

Dural AV fistula

A

Usually idiopathic acquired
Most common documented cause is neovascularity from thrombosed dural venous sinus, typically transverse
Those that have cortical venous drainage have risk of bleeding and of neurological compromise. Those that drain direct to sinuses are benign.

Spinal - hypoperfused spine because of venous congestion, intramedullary oedema - conus often involved as dependent, regardless of location of AVF - AVF is most common spinal vascular malformation

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21
Q

Pituitary microadenoma

A

Dynamic MR delayed enhancement

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22
Q

Laryngeal cancer

A

Subglottic 5%, late detection and poor prognosis (inferior cricoid to true fold). Spares lymphatics.
Glottic 50-60% manifests early with hoarse voice, and tends not to met because of lack of lymphatic drainage. >90% 5yr survivial
Supraglottic 20-30% early lymph node metastases

Smoking, alcohol, HPV, turkish coffee, asbestos

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23
Q

Myxopapillary ependymoma

A
Most common tumour of conus / filum
WHO1
May have CSF dissemination
May haemorrhage, calcify
T2 high and enhance
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24
Q

Basal cisterns anatomy

A

Interpeduncular cistern
Quadrigeminal cistern - between colliculi, splenium, and superior cerebellum
Ambient cistern - laterally surrounds midbrian, connects quadrigeminal to interpeduncular
Cisterna magna
Suprasella
Pre-pontine etc

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25
Q

Temporal bone CT anatomy

A

.

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26
Q

Ivory vertebra

A
Blastic met
Lymphoma
Haemangioma
Chordoma
Pagets
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27
Q

Basilar tip thrombus

A

Also - artery of percheron - single trunk to bilateral medial thalami and rostral midbrain

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28
Q

Subependymoma

A
2/3 infratentorial
grade 1, middle, older aged
neurocytomas are in younger patients
Ependymomas also in younger
Small and don't enhance
50% become symptomatic
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29
Q

Cavernoma

A
Rim of signal loss - haemosiderin
Angiographically occult
Rarely familial
Associated with radiotherapy
20% have a DVA
Imaging classification - Zabramski
Differential of other multiple bleeding lesions:
HTN or amyloid angiopathy
Mets
DAI
Vasculitis
30
Q

Throat anatomy on CT

A

.

31
Q

Odontoma

A

Tooth hamartoma
Complex - calcified but no identifiable tooth components
Compound - tooth components
Half associated with an unerupted tooth
Typically second decade
The most common odontogenic tumour of mandible

May give rise to a dentigerous cyst

“well defined lesion with identifiable tooth components…” or just with calcified components

32
Q

Glomus jugulare

A

More common than globums vagale
Grow into middle ear
Cause middle ear symptoms and cranial nerve ones

33
Q

Facet joint synovial cyst

A

Lumbar spine most common
May be a calcified mass
Adjacent joint may have OA
Can peripherally enhance

34
Q

Dural sinus thrombosis

A

Higher risk in puerperium than pregnancy
Can cause pseudotumour cerebri (intracranial hypertension)
Other risks: infection, inflammation, neoplasia (meningioma - mechanical compression), dehydration, thyrotoxicosis, cirrhosis

35
Q

PRES

A
Disordered autoregulation of perfusion
HTN and endothelial dysfunction
Vasogenic oedema in parietal and occipital lobes
Otherwise mainly in watershed areas
Infarcts in 10-25%. Haemorrhage 15%
36
Q

Cochlear promontory

A

Bone overlying basal turn of cochlear, protrudes into middle ear.
Glomus tymanicum arise here

37
Q

MR intracranial blood products

A

Hyperacute - isoiso - intracellular oxy
Acute - isohypo - intracellular deoxy
Early subacute - hyperhypo - intracellular met
Late subacute - hyperhyper - extracellular met
Chrnoic - lowlow - haemosiderin

38
Q

BLL

A

Benign lymphoepethlial lesion
Mixed solid and cystic lesion of parotids in HIV patient
Commonly cervical node enlargement also

39
Q

HIV

A

PML, HIV encephalitis (/ HIV associated dementia)
(and toxoplasmosis, lymphoma)
Progressive multifocal leukoencephalopathy
Demyelination from JC reactivation
Subcortical U fibres commonly involved
Asymmetric periventricular and subcortical demyelinating foci - middle cerebellar peduncel and adjacent pons and cerebellum typical
Uncommonly diffusion restrict, doesn’t enhance
Cf HIV which has symmetric T2 abnormality with sparing of subcortical white matter

40
Q

CADASIL

A

Cerebral AD arteriopathy with subcortical infarcts and leukoencephalopathy
Microvasculopathy
Confluent white matter T2 hyperintensities

41
Q

White matter disease

A

Idiopathic/inflammatory/autoimmune eg MS
Toxic eg Machiafava bignami, Werneckes, osmotic
Vascular - CADASIL, PRESS, microangiopathy, vasculitis
Infectious: PML, SSPE (Measles)
Post-infectious: ADEM
Iatrogenic: Radiation, chemotherapy

42
Q

Gliomatosis cerebri

A

Growth pattern
Most commonly in anaplastic astrocytoma
At least 3 lobes
Diffuse T1 low and T2 high

43
Q

ADEM

A
Post viral
Basal ganglia and spinal cord
Can involved gray matter
Acute disseminated encephalomyelitis
Hurst disease is fulminant haemorrhagic course
Sligh male predominance
Systemic symptoms
Peak 3-5 age
44
Q

CJD

A
T2 up in cortex, basal ganglia, thalami
Diffusion restricts
No significant atrophy, significant rapidly progressive dementia
Normal form sCJD, 7 month survival
vCJD 16 month - hot cross bun sign
Familial 10-15% - 26 month survival
45
Q

J-shaped sella

A
Flattening of tuberculum sellae (anterior margin of sella)
Normal variant (5%)
Optic glioma
Hydrocephalus
MPS
NF
Achondroplasia
46
Q

Dilated Virchow-Robin spaces, types

A

Type 1 - basal ganglia (lenticulostriate)
Type 2 - entering cortex (perforating medullary)
Type 3 - midbrain

47
Q

Dilated VR spaces, causes

A
Normal variant
Lacunar infarct
Amyloid angiopathy
Microangiopathy
Infectious - cryptococcus, neurocystercicosis, TB
MPS
Sarcoid
Metachromatic leukodystrophy
Sturge-Weber
Meningiomatosis
48
Q

MELAS

A

Stroke like episodes in late childhood or early adulthood

MORE HERE

49
Q

Hallevorden-Spatz

A

Iron deposition in brain
Low T2 globi pallidi, with T2* blooming in same areas
Dementia

50
Q

Basal ganglia disease

A

CO - T2 high signal in globi pallidi
Methanol tends to affect putamen
Mitochondrial disorders affect other parts of basal ganglia) E.g. Leighs AKA SNEM, (predominantly putamina)
Wilsons disease has global basal ganglia T2 high
CJD also affects basal ganglia, and cortex, with diffusion restriction and T2 high

51
Q

Intraventricular mass

A
Central neurocytoma
Choroid plexus
Ependymoma
Subependymoma
SEGA
Oligodendroglioma
Meningioma - most common trigonal mass
Lymphoma

Central neurocytoma and oligo may be mistaken both histo and radio

52
Q

Otosclerosis

A

.

53
Q

Vestibular aqueduct

A

Normal <1.5mm

54
Q

Thyroid ultrasound, suspicious features

A
Microcalc
Extension beyond thyroid
Lymph nodes
Taller than wide
Markedly hypoechoic
Ill defined
Increased central vascularity
55
Q

Thyroid nodule FNA indications

A
>1cm solid with suspicious features
>1.5cm solid without suspicious features
>1.5cm mixed solid cystic with suspicious features
>2cm mixed without suspicious features
>50% growth from previous
56
Q

Normal pressure hydrocephalus

A

Callosal angle <90 degrees (perpendicular to the anterior / posterior commisure plane at level of posterior commisure)
Evans index >0.3 (Maximum width of frontal horns to internal skull diameter at same level)
CSF flow >24.5mL/min (aqueduct)

57
Q

Kimuchi disease

A

.

58
Q

Kimura disease

A

.

59
Q

Scerosing sialadenitis

A

.

60
Q

Dentigerous cyst

A

Surround crown - unilocular well defined lucency, centred on crown
Mandibular 8 > maxillary 8 > maxillary canine > mandibular 5
Associated with MPS and basal cell naevus
(KCOT may mimic)

61
Q

Mandibular and maxillary tori

A

Dense compact bone, often without medulla
Benign
Inwards from mandible, or in or outwards from maxilla

62
Q

Ameloblastoma

A

Multicystic, soap-bubble lesion, may erode roots of teeth (and cortex) (KCOT tends to be unilocular, but can mimic)
Benign and locally aggressive
May be associated with a dentigerous cyst

Identical to adamantinomatous craniopharyngioma on histology (used to be called adamantinoma of jaw)

2nd most common ondontogenic tumour (after odontoma)

63
Q

Lytic lesion of jaw

A

Dentigerous cyst
Ameloblastoma (soap bubble, multilocular
KCOT (uniclocular)
Giant cell reparative granuloma (anterior jaw, honeycomb multilocular. Histo may be identical to ABC according to radpaed)
ABC
Brown tumour
Stafne cyst (pathognomonic appearance, not a true cyst, between molars and angle of jaw)
Cherubism (multiple soap-bubble lesions - fibrous dysplasia)

64
Q

Mucocele, paranasal sinus

A

Expanded obstruced sinus, opacified by mucous
Bony margin may be thinned
May have peripheral enhancement
An polyp and a retention cyst won’t completely fill the sinus
Tumour such as sinonasal carcinoma and inverted papilloma will enhance

65
Q

Neurocysticercosis

A

Tapeworm Taenia solium
Humans act as definitive host - tapeworms in the intestine after humans ingest larval cysts from undercooked pork meat (pigs are intermediate host)
Cysticercosis is extra-intestinal, from faecal oral spread / autoinfection. Ingestion of eggs. Larval form incites an inflammatory reaction which over a period of time undergoes calcification
CNS, eyes, skeletal muscle, subcut tissues
Rice grain calcification in muscles

Subarachnoid (most common, over hemispheres), subcortical (2ndmost after subarach) and ventricular cysts (4th ventricle most common)
Parenchymal cysts are small, 1cm, whereas subarach may be 9cm

Cyst with dot sign - eccentric scolex (the end of the tapeworm - the scolex may enhance and be hyperintense on T1)

Cyst with enhancing rim. Not diffusion retricting. In early phase may not have much enhancement.

Seizures
Headaches, hydrocephalus
Decreased consciousness

4 stages:
Vesicular - viable parasite, no reaction
Colloid vesicular - cyst with oedema, most symptomatic
Granular nodular - cyst starts to retrace
Nodular calcified - end stage

66
Q

Calcifying intracranial tumours

A
Craniopharyngioma (rare in papillary variant), meningioma, chondrosarcoma, chordoma
Central neurocytoma
Ependymoma
Subependymoma
Ganglioglioma
Cavernous haemangioma
Dermoid
Pineoblastoma / cytoma
Pineal germinoma
Olfactory neuroblastoma
DNET (more microscopic)
ATRT
Oligodendroglioma
67
Q

Ring-enhancing cerebral lesion

A
Abscess
Tumour (met of GBM)
Demyelination
Neurocysticercosis
Subacute infarct, haemorrhage, contusion
Lymphoma in immunocompromised
Radiation necrosis
Tuberculoma
68
Q

Lymphoma CNS

A

.

69
Q

Zabramski classification

A

Of cavernomas
1 - acute haemorrhage - T1 high, T2 low or high
2 - Classic popcorn lesion - peripheral haemosiderin rim, mixed central T1 and T2
3 - chronic haemorrhage - T1 and T2 low centrally
4 - Multiple punctate microhaemorraghes - best seen just on SWI

70
Q

Mixed vascular malformation

A

Cavernoma + DVA

DVA rarely bleed, but

71
Q

Cavernoma

A

20% have a DVA
Associated with radiotherapy
Angiographiccaly occult
Can hav familial multiple cavernomas

72
Q

Proptosis, orbital mass

A

Most common proptosis - thyroid eye disease: usually bilateral symmetric, can cause optic nerve compression and blindness. IMSLO. Tendon usually spared but involved in 8%)
Painless: lymphoma, sarcoid, meningioma (lymphoma usually upper outer, separate to muscles, rarely causes blindness. Sarcoid usually lacrimal)
Painful: Pseusdotumour (usually muscle, involves tendon) Cellulitis, Wegeners (usually bilateral circumferential),
Also orbital mets, rhabdomyo, ocular melanoma, lacrimal gland can have adenoid cystic carcinoma, adenocarcinoma