Practice Test 1

Question 1

Attached to proteins to target them for proteolic degradation

Answer 1

Ubiquitin

Question 2

Clamp protein that donates processivity to Eukaryotic DNA Polymerase

Answer 2

PCNA

Question 3

Activated by single strand and double strand breaks in DNA and phosphorylates s15 on p53

Answer 3

ATM

Question 4

Protein activated in expression by p53 which participates in loading PCNA/ DNA Polymerase complexes at sites of DNA repair and inhibits start kinase

Answer 4

p21

Question 5

Major coactivator of transcription which binds to phosphorylated upstream transcription factors with its KIX Domain

Answer 5

CBP

Question 6

Covalently ligates ubiquitin to p53

Answer 6

Mdm2

Question 7

Opens holes in mitochondrial outer membranes to induce apoptosis

Answer 7

Bax

Question 8

Produces cuts in DNA at site of mutations

Answer 8

Repair endonuclease

Question 9

Upstream transcription factor which is phosphorylated by PKA

Answer 9

CREB

Question 10

76 amino acid protein attached to lysines on a protein to label it for proteolysis

Answer 10

Ubiquitin

Question 11

Kinase activated by cAMP (cyclic adenosine monophosphate)

Answer 11

PKA

Question 12

Upstream transcription factor which is called a tumor suppressor because it acts to prevent cancer

Answer 12

p53

Question 13

Activated by ATM and phosphorylates p53 at s20, preventing its interaction with Mdm2

Answer 13

Chk2 kinase