Practice Quiz 2, Exam 5

Question 1

In response to moderate levels of DNA damage and consequent p53 levels in the cell, what does p53 activate the expression of?

Answer 1

p21

Question 2

p21 inhibits

Answer 2

Start kinase

Question 3

p21 loads DNA Polymerase delta to repair sites through its interaction with

Answer 3

PCNA

Question 4

In response to high level of DNA damage and consequent p53 levels within the cell, what does p53 activate the expression of?

Answer 4

Bax

Question 5

Anti-apoptic proteins that heterodimerizes with Bax

Answer 5

Bcl-2

Question 6

In response to the Bax-ringed holes in the outer membrane, this protein leaks out to form the apoptosome

Answer 6

Apaf1

Question 7

The apoptosome rearranges the structure of two of this so that they make a proteolic cut in each other, initiating the protease cascade that leads to apoptosis

Answer 7

Procaspase-9

Question 8

Caspase-9 product

Answer 8

Caspase-3

Question 9

Caspase-3 target

Answer 9

ICAD

Question 10

Cuts the DNA of the cell into nucleosome-sized pieces

Answer 10

CAD

Question 11

Region of the epidermis that undergoes apoptosis due in the reduction of expression of Bcl-2

Answer 11

Stratum granulosum

Question 12

Consequent of excessive DNA damage to the basal layer of the epidermis

Answer 12

Sunburn

Question 13

Activates cell division to repair consequences of sunburn

Answer 13

EGF