Practice quiz content Flashcards
Which genetic diseases are caused by an increase in the number of nucleotides in the DNA of the affected gene or it’s upstream region?
Huntington disease and Fragile X Syndrome
Which type of Down Syndrome results in a karyotype of 45 chromosomes?
Down Syndrome due to translocation
What is the normal function of RB proteins?
Binds to protein E2F to prevent the cell from entering S phase
What is the normal function of MLH1 proteins?
Corrects DNA base-pair mismatches
What is the normal function of BRCA1 proteins?
repairs DNA or triggers apoptosis
What is the normal function of VHL proteins?
controls angiogenesis
What is the difference between DNA sequence mutations and epigenetic modifications?
epigenetics modifications can be reversed
What does nondisjunction during gametogenesis refer to?
the failure of the chromosomes to separate during production of sperm and egg
What does epigenetics play an important role in?
cellular differentiation, heterochromatin maintenance, and X chromosome inactivation
Which hormones increase during ACUTE stress?
Epi and NE
What hormone levels increase during prolonged stress?
Human growth hormone, cortisol, epi, glucagon, T3 and T4, NE
What is the most commonly reported symptom of cancer treatment?
fatigue