Practice questions Flashcards
How do you record an ADR?
A Yellow Card can be submitted: Via the MHRA Yellow Card website (https://yellowcard.mhra.gov.uk/). Via a free Yellow Card mobile app. By post. Using some clinical IT systems such as the MiDatabank system, SystmOne, and Vision. Members of the public can also report suspected ADRs (by using the Yellow Card Scheme).
what does lipid solubility mean?
The concentration of a chemical that will dissolve in fatty substances
What does distribution mean?
Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body.
How do statins work to lower serum cholesterol levels?
They stop the production of cholesterol by blocking the enzyme that creates it.
Reduced production lowers the total amount of cholesterol available in your bloodstream
what is the standard antidote for opiate overdose?
Naloxone
What is the treatment for paracetamol overdose?
intravenous acetylcysteine
What do you understand about the cytochrome P450?
Cytochrome P450 (CYP450) are a group of enzymes encoded by the P450 genes and responsible for the metabolism of most drugs seen in clinical practice
A drug that binds to a cell receptor and affects a response is called ?
Agonist
Most drugs and metabolites are excreted by?
The kidneys
The four processes in pharmacokinetics are?
Absorption. Distribution. Metabolism. Excretion
Pharmacodynamics is defined by?
The affect the drug has on the body
The main method of renal elimination of a drug is by?
Active glomerular filtration
What route should a drug be given if subject to complete destruction by first pass metabolism be given?
IV
A pro-drug is?
A drug given in its inactive form, requiring metabolism
Pharmacodynamic interactions can occur when?
The action of one drug competes with the action of another
