Practice Q's Flashcards
true or false
the rate of zero order reactions IS dependent on temperature
true
true or false
the rate of zero order reactions is dependent on concentraiton
false - independent
true or false
the rate of zero order reactions is different for every drug, but the same for the same drug
true
(dC/dt) = KC
describes _________- kinetics
first-order kinetics
true or false
the rate of first order degradation is independent of concentration
FALSE
for first order degradation, ____________ yields a straight line
a plot of log of concentration vs time
true or false
the half life is a changing parameter for first-order degradation of a drug
FALSE - CONSTANT
true or false
an increased surface area may enhance the dissolution rate of powders
true
true or false
milling powders may cause the degradation of photolabile drugs
FALSE - may cause the degradation of thermolabile drugs
in the milling of powders, what particle size is essential for the lubricant to function properly
FINE particle size
for which of the following can divided powders be dispensed:
bulk container
individual dose packets
sifter-type container
individual dose packets
name 2 substances that are used to insulate powder components that liquefy when mixed
kaolin
light magnesium oxide
true or false
talc is a substance used to insulate powder components that liquefy when mixed
false
what is the function of a glidant in tablet formulation
improving the flow properties of the granules
true or false
it is not the function of a glidant to reduce punch and die wear
true
true or false
it is the function of a glidant to facilitate tablet ejection from the die
false
give 2 possible reasons for the capping of a tablet
excessive pressure during compression
too dry of a granulation
true or false
excessive lake pigments can be a reason for capping of a tablet
false
true or false
carnauba wax is commonly used to coat film-coated tablets
FALSE
name 2 agents commonly used to coat film-coated tablets
HPC (hydroxypropyl cellulose)
HEC (hydroxyethyl cellulose)
true or false
lubricants do not help the patient to swallow the tablet
true
________ promote granulation during the _ granulation process
binders, wet
if a drug is known to be susceptible to extensive GI degradation and/or first pass effects, how can you achieve a systemic therapeutic levels for this drug for prolonged duration?
a controlled release drug delivery system for ocular delivery
change route of administration – cant be GITS (gastrointestinal system)
true or false
in zero order kinetics compared to first order kinetics, there is less drug-plasma protein binding
false
same drug will bind same proteins regardless of kinetics
true or false
bioavailability does not vary with kinetics
true
name an advantage of zero order kinetics over 1st order
zero order has more precise plasma concentration (STEADY STATE)
why should Procardia XL not be crushed
DOSE DUMPING
active drug will be immediately absorbed and the integrity of the delivery system is destroyed
true or false
when procardia XL is chewed, the active drug is not destroyed
true
the active drug is not destroyed, the delivery system is
true or false
Slow-K is a membrane device
FALSE - MATRIX
true or false
Gradumet contains coated granules
false - combined with inert polymer in inert plastic matrix
Spansule capsules use what technology
dissolutionsystem
