Practice Q's

Question 1

true or false

the rate of zero order reactions IS dependent on temperature

Answer 1

true

Question 2

true or false

the rate of zero order reactions is dependent on concentraiton

Answer 2

false - independent

Question 3

true or false

the rate of zero order reactions is different for every drug, but the same for the same drug

Answer 3

true

Question 4

(dC/dt) = KC

describes _________- kinetics

Answer 4

first-order kinetics

Question 5

true or false

the rate of first order degradation is independent of concentration

Answer 5

FALSE

Question 6

for first order degradation, ____________ yields a straight line

Answer 6

a plot of log of concentration vs time

Question 7

true or false

the half life is a changing parameter for first-order degradation of a drug

Answer 7

FALSE - CONSTANT

Question 8

true or false

an increased surface area may enhance the dissolution rate of powders

Answer 8

true

Question 9

true or false

milling powders may cause the degradation of photolabile drugs

Answer 9

FALSE - may cause the degradation of thermolabile drugs

Question 10

in the milling of powders, what particle size is essential for the lubricant to function properly

Answer 10

FINE particle size

Question 11

for which of the following can divided powders be dispensed:

bulk container
individual dose packets
sifter-type container

Answer 11

individual dose packets

Question 12

name 2 substances that are used to insulate powder components that liquefy when mixed

Answer 12

kaolin
light magnesium oxide

Question 13

true or false

talc is a substance used to insulate powder components that liquefy when mixed

Answer 13

false

Question 14

what is the function of a glidant in tablet formulation

Answer 14

improving the flow properties of the granules

Question 15

true or false

it is not the function of a glidant to reduce punch and die wear

Answer 15

true

Question 16

true or false

it is the function of a glidant to facilitate tablet ejection from the die

Answer 16

false

Question 17

give 2 possible reasons for the capping of a tablet

Answer 17

excessive pressure during compression
too dry of a granulation

Question 18

true or false

excessive lake pigments can be a reason for capping of a tablet

Answer 18

false

Question 19

true or false

carnauba wax is commonly used to coat film-coated tablets

Answer 19

FALSE

Question 20

name 2 agents commonly used to coat film-coated tablets

Answer 20

HPC (hydroxypropyl cellulose)

HEC (hydroxyethyl cellulose)

Question 21

true or false

lubricants do not help the patient to swallow the tablet

Answer 21

true

Question 22

________ promote granulation during the _ granulation process

Answer 22

binders, wet

Question 23

if a drug is known to be susceptible to extensive GI degradation and/or first pass effects, how can you achieve a systemic therapeutic levels for this drug for prolonged duration?

Answer 23

a controlled release drug delivery system for ocular delivery

change route of administration – cant be GITS (gastrointestinal system)

Question 24

true or false

in zero order kinetics compared to first order kinetics, there is less drug-plasma protein binding

Answer 24

false

same drug will bind same proteins regardless of kinetics

Question 25

true or false

bioavailability does not vary with kinetics

Answer 25

true

Question 26

name an advantage of zero order kinetics over 1st order

Answer 26

zero order has more precise plasma concentration (STEADY STATE)

Question 27

why should Procardia XL not be crushed

Answer 27

DOSE DUMPING

active drug will be immediately absorbed and the integrity of the delivery system is destroyed

Question 28

true or false

when procardia XL is chewed, the active drug is not destroyed

Answer 28

true

the active drug is not destroyed, the delivery system is

Question 29

true or false

Slow-K is a membrane device

Answer 29

FALSE - MATRIX

Question 30

true or false
Gradumet contains coated granules

Answer 30

false - combined with inert polymer in inert plastic matrix

Question 31

Spansule capsules use what technology

Answer 31

dissolutionsystem