Practice Flashcards
Describe the concentration of Ca+ in alkalotic and acidotic condition?
Ca2+ and H+ compete with one another.
Acidic conditions–> High H+–> H+ will bind to albumin and we will have high levels of free Ca+
Alkalotic condition–> not alot of H+, so Ca2+ will bind–> decrease of free Ca2+
Where does the reabsorption of Phosphate?
80% reabsorbed by PT
What causes an increase in Mg reabsorption?
- PTH
- Volume contraction
- Metabolic alkalosis
What is the biggest regulator of plasma phosphate levels
PTH
What is PTH’s MAIN/primary job?
Regulate Ca2+ levels.
What stimulates Calcitriol production?
PTH stimulates calcitriol producton in renal proximal tubular cells by upregulating renal- 1alpha hydroxylase
K+ can be thought of as a vas______
Potassium= VASODILATOR
PTH does what to bone
results in the release of Ca2+ and phosphate from the bone
PTH inhibits Pi reabsorption in the ________
PT
Why does ACE-Inhibitor not affect Na+ concentration
- ACE-I inhibits Na and h2o reavsorption in the same degree, so the concentration in plasma would not increase cause same amount of water and na are being excreted
- k + increases due to less na being reabsorbed which means less na/k atpase activity which means less K secretion and more reabsorption
Why does chronic acidosis increase P secretion?
- Because there is a downregulation of Na/P symporter in the apical membral membrane
- Pi shifts from the ICF–> ECF
What is the major stimulus for PTH secretion?
Hypocalcemia
The release of intracellular K+ is expected to be a consequence of what?
Intracellular buffering of H+ ions.
In alkalosis, predicted movement of K+ is where?
Into the cells, leading to hypokalemia.
-this is d/t the intracellular buffering of H+. There is increased exchange of the for H+ for Na+ using the HNa antiporter on the cell, which would acceelerate intracellular K+ accumalotion via the Na/K ATPase
Na/K ATPase can be activated by _____ in the PCT; and activated by ___ in the TA
A1 and B1
