Pract 5, 6, 7 Flashcards
Solution:
- System: Homogenous disperse
- Solvent: liquid
- Solute: Solid/gas/liquid
- Precipitate: No, clear
Emulsion:
- System: heterogenous dusperse (o/w, w/o)
- Solvent: liquid
- Solute: liquid
- Precipitate: yes, liquid
bigger than 500nm = NEVER IV
Suspension:
- System: heterogenous disperse
- solvent: liquid
- solute: solid
- precipitate: yes, solid
bigger than 500nm = NEVER IV
Microemulsion/microsuspension:
very small -> can be used IV
Microemulsion:
- propofol
- microlipid infusion (used when they cant eat)
Microsuspension:
- Fenbendazole and Flubendazole = antiparasitic agent. Fine powderm miced in water.
W/O and O/W systems:
- Weaper O: w/o = oil is the largest phase. water in oil
- Oper W: o/w = water is the largest phase. Oil dissolved in water
Injection vs Infusion
both: Liquid - parenteral
Injection (injectio):
- solution, Emulsion, Suspension, Microemulsion, Microsuspension
- smaller than 100ml
Infusion (infusio):
- solution, microemulsion
- More than 500ml
can be given SC
Injection, infusion - requirements:
Requirement for all:
- sterile
- pyrogen-free (pyrogen = fever)
- isotonic
- isohydric (pH between 5 and 7)
+ homogenous, particle free (solution)
Liquids for Oral and Rectal use:
- solution
- emulsion
- suspension
- syrup (sirups): better taste, much sugar. not frequently used in Vet.med
- Elixir, mixture: have alcohol content. Do not give in case of liver failure
- Extract (extractum, Tinctura): can be dry, water and alcoholic. Substract substances from herbal parts. Do not give to liver failure patients!
- Drop for oral use (Gutta): when you only need a small dose. Not frequently used.
Liquid for skin, mucous membrane:
- solution
- emulsion
- suspension
- spot on/ pour on
- shampoo
- teat dip solution
- extract
- inrauterin solution, suspension
Liquid for ophthalmology:
- solution, suspension
- sterile!
- active agent (AB, GC, NSAID, emetics, drug acting on autonomous NS)
- vehicle: same as binders, give volume (Water, castor oil, but sterile!)
- preservative (benzalkonium chloride)
- expiration date: quicker when you open it, only for four weeks.
Difference between Steriods and NSAIDS in ophthalmology:
Steroid:
- glucocorticoids
= causes immune suppression, so never use incase of viral infections
= decrease the healing of cornea
= use flourossence test –> turns green in case of damage
Liquid for - Otology, nasal cavity
- Ear cleaner: contain detergent and antiseptic agent to remove the discharge
- Ear drop (otogutta):
- solution, suspension
- active agent (AB, antifungal, GC, antiparasitic…)
- vehicle (water, alcohol, propylene glycol…)
- Malassezia pachydermatitis: yeast fungi in otitis externa
- Pseudomonas aeroginosa: bacteria in otitis externa - Nasal drop (nasogutta): BbPi
- nasal spray
Semi-solid:
- field of application and dose form:
- Skin, mucous membrane:
- Ointment (unguentum), Cream (cremor), Gel (gelum) - Oral:
- Gel (gelum), Paste (pasta), Electuaries (Electuarium) - Eye:
- Eye ointment (Oculentum) - Mammary gland:
- Intraammary infusion - Rectum, Vagina:
- Suppository (suppositorium), Vaginal suppository (Ovulum)
Semi-solid:
- properties
- active agent - various
- homogenous appearance:
- body temp does not melt it
- local or systemic effect
Semi-solid ointment Active compounds:
- Antibiotics, antimycotic, antiviral agents.
- NSAIDS, glucocorticoids, antihistamine
- coating, antiseptic agents
Semi-solid ingredients:
VEHICLE:
Lipophilic:
- fats and oils: cocoa butter, oils (sunflower, eanut, castor, cod liver oil), hard fat
- hydrocarbons: vaseline and paraffins
- Waxes and wax alcohols: wool wax (Lanolin), honey bee wax, cetostearyl alcohol
= can not wash it with water, longer duration than hydrophilic
Hydrophilic:
- natural polymers: cellulose, gelatine, starch
- syntehtic polimers: macrogols (polyxyethylenes), and polysorbates (tween).
Semi-solid ointment w/o:
can not be washed with water
- hydrous ointment
- emollient ointment
- (simple ointment)
- (oily ointment)
Semi-solid ointment o/w:
- nonionic hydrophilic ointment
- anionic hydrophilic ointment
- (noniunic emulsifying ointment)
- (anionic emusifyying ointment)
Semi-solid:
cream, gel
Cream:
- emuslion system
- hydrophilic o/w
–> emulsifiers: Na-soap, Polysorbate
- lipophilic w/o
–> emuslifiers: Wool wax alcohol
Gel:
- gellifying agent: starch, cellulose, colloid SiO2