PPt. 1-3 Flashcards
Generally takes __ days for conceptus to migrate from fallopian tube into uterus
8
when is the fertilized egg independent of environment but not of genetics
pre-embyronic phase
8 days from fertilization to implant
when is the embryonic phase
weeks 3-8
the time when all of the tissues are specializing and organs are forming
Period of Organogenesis
when is the Period of Organogenesis
embryonic phase
weeks 3-8
-Time when malformations occur and greatest vulnerability to teratogens
Period of Organogenesis during the embryonic phase (weeks 3-8)
Embryonic development into what 3 germ layers
- Ectoderm will become skin and nervous system
- Mesoderm will become muscle and bone
- Endoderrm will become GI tract (alimentary canal), endocrine and respiratory systems
When can you start to see the heart beat
on 6 week ultrasound
When is the fetal phase
9 weeks until delivery
What happens during the fetal phase
Further growth, differentiation and maturation of organs
when do Pulmonary alveoli begin to develop
24 weeks
When does surfactant present in lungs
at 34 weeks
What is the importance of surfactant
it reduces the surface tension of lungs to keep the alveoli open so baby can breath
What happens if the baby is born before 24 weeks
pulmonary alveoli won’t be develooped and the fetus won’t be viable outside the womb
Fetal membranes and what do they do
Amnion is inner layer
Chorion is outer layer
Function: act to protect fetus from injury and infection
What happens when a mother’s water breaks
the fused chorion/aminion membrane ruptures and amniotic fluid poors out
PROM
prolonged rupture of membranes > 18 hr
*prior to delivery- makes you prone for infection
PPROM
premature, prolonged ROM
*breaks prior to 35 weeks of gestation
SROM
spontenous ROM
AROM
artificial ROM
*can have AROM that becomes PROM
What are the functions of amniotic fluid
- Acts as a cushion for fetus as mother moves
- Prevents membranes from sticking to baby
- Allows for fetal movement
- Necessary for lung development
How does the fetus contribute to the placenta
Chorionic villi
Finger-like projections of chorion which penetrate into the endometrium, the lining of the uterus
Chorionic villi
what does a chorionic villi contain
- fetal arteriole, venule, and capillary
What is the placenta made up of
- Chorionic villi- fetal contribution
2. Decidua Basalis- maternal contribution
What happens when c.villus invades the endometrium
it causes the maternal capillary beds to break down into sinusoids
blood flow in placenta
arteriole –> open space –> venule
Where is the fetal capillary
sits within the sinusoid and is bathed by maternal blood
*drug transfer occurs this way
Mother to fetus exchange across the placenta
oxygen, aminio acids, fats, glucose, some hormones, antibodies, most drugs, viruses
Fetus to mother exchange across the fetus
carbon dioxide, bilirubin, ammonia and other waste products
“crossing the placenta” refers to
the diffusion of molecules in either direction
What happens if mom has DM1 and has high blood sugars high throughout the pregnancy. Therefore baby see lots of maternal glucose in utero but what happens with insulin?
- insulin does not cross placenta because too big of a molecule, therefore baby’s pancreas produces its own insulin to take care of mother’s glucose
- baby continues to produce insulin after birth and becomes hypoglycemic–> may require force feeding
What produces hCG
the chorion (or more generally the placenta)
What hormones maintain the lush endometrium necessary to sustain pregnancy
hCG and progesterone
When is there enough hormones for a pregnancy test to detect pregnancy
2 weeks post conception
maternal blood and urine
What hormone does a pregnancy test detect
hCG
when does ovulation occur
14 days before menstruation (regardless of cycle length)
How do you date pregnancy?
date pregnancy counting 40 weeks from first day of last menstrual period
When does pregnancy actually start occuring, when dating pregnancy
2 weeks before ovulation and fertilization
Whats the purpose of ultrasounds
- Dating pregnancy
- Evaluating anatomy
- Checking position of placenta (important for C-sectino and wanting a chorionic villi sample)
- Checking volume of amniotic fluid
Useful early on in pregnancy because can get closer to fetus and give more accurate images in first weeks
transvaginal u/s
Disadvantage of transvaginal u/s
uncomfortable for mother (its tucked under the cervix)
More standard u/s
transabdominal u/s
what do you measure with U/S dating in 1st trimester and what is its accuracy
Measure crown-rump length
Accurate +/- 3 days
what do you measure with U/S dating in 2nd trimester and what is its accuracy
Measure biparietal diameter
Accurate +/- 1 week
what do you measure with U/S dating in 3rd trimester and what is its accuracy
measure biparietal diameter
Accurate +/- 2 weeks
Why is it important to accurately date your pregnancy
- Surfactant develops around 35 weeks
- know the development of other systems
Why is dating less accurate later on in the pregnancy?
genetics, environmental factors, difficult to visualize teh baby due to its position and limbs
What is considered the 1st trimester
weeks 1- 12
What is considered the 2nd trimester
weeks 13- 28
What is considered the 3rd trimester
weeks 29- delivery
what is considered the ideal term?
40 weeks, or 38-42 weeks
no later than 42 weeks bc placenta starts to die off and baby gets too big
Can maternal antibodies cross the placenta
yes
Rh incompatibilty
mismatch between maternal and fetal blood types that results in mother making anitbodies to fetus blood cells and results in hemolysis of fetus RBC
What can Rh incompatibilty cause
jaundice hydrops fetalis (total body edema)
Prenatal screening consists of:
- Rh compatibility
- u/s for anatomy
- Glucose tolerance test (16 weeks)
- option gentic screening
- Hep B*
- HIV*
- Syphilis, Gonorrhea, Chlamydia*
* at first prenatal visit - Immunity to Rubella (conferred by vaccine)
- GBS at 36- 37 weeks
- Alpha fetoprotein
- other disease specific to population
when is the best time to do an u/s for anatomic survey
18-20 weeks when all the organs have formed
later than that then baby is too large to see details bc of superimpsed body parts
what type of u/s do you do for an anatomic survey
transabdominal
Optional screening offered to patients deemed to be at increased risk of having baby with genetic problems:
- Advanced maternal age (35 or older)
- Abnormal findings on prenatal ultrasound
- Family history of genetic disorder
- Previous miscarriages
what are the 2 forms of genetic testing
- amniocentesis (go through abdomin)
2. chorionic villus sampling (go through abdomin or up vaginal canal)
pros and cons of amniocentesis
P: can do whenever during pregancny
C: 1. mom can have cramping
2. can introduce bacteria to baby
3. can nick the baby or the cord
pros and cons of chorionic villus sampling
P: less risk
C: can only perform in a certain time frame (11-14 weeks)
Fasting blood sugar provides a baseline for comparing other glucose values
glucose tolerance test, testing for maternal diabetes
Pregnant women drink ___ grams of glucose.
Blood samples will be collected at timed intervals of __ and ___ hours after patient drinks the glucose.
drink 75grams of glucose
collect at intervals of 1 and 3 hrs
when is the glucose tolerance test performed
16 weeks
when do you screen for GBS
36- 37 weeks
What does alpha fetoprotien screen for
- high in neural tube defects
- low in down syndrome
“Ashchkinasi screen”
for diseases found in people of European Jewish descent
The process by which products of conception (baby, placenta, cord and membranes) are expelled from the uterus
labor
Requires progressive effacement (thinning) and dilation of the cervix, resulting from rhythmic contractions of the uterine muscles
labor
Dilatation in absence of contractions
cervical insufficiency
ways to decrase cesarean deliveries
- allow prolonged latent (early phase labor
- changing the definition of active labor to start at 6 cm (instead of 4cm)
- Allowing more time for labor to progress in the active phase
- Allowing women to push for at least two hours if they have delivered before, three hours if it’s their first delivery, and even longer in some situations, for example, with an epidural.
- Using techniques to assist with vaginal delivery, which is the preferred method when possible. This may include the use of forceps, for example
- Encouraging patients to avoid excessive weight gain during pregnancy.
Process whereby baby’s heart rate and its response to uterine contractions is monitored
fetal monitoring
what is a normal fetal heart rate
120-160 bpm and should show variability
Fetal heart rate usually _____ with contractions
increases
_______ after contraction or _________ are abnormal
decelerations
slow recovery to baseline
Decelerations after contraction can indicate
- stress
2. need for operative intervention
This type of monitoring uses a doppler to pick up the babies heart rate and tocodynamometer to measure the intensity of contractions
external monitor
cons on external fetal monitoring
sussceptible to artifact and requires that mom and baby remain relatively still
An electrode screwed to the babys scalp can accurately measure fetal heart rate including subtle variations
internal fetal monitoring
Cons of internal fetal monitoring
requires rupture of membranes leaving potential site of infection
Late decelerations are associated with
uteroplacental insufficiency or decreased uterine blood flow
The pain of labor and delivery is a result of
muscular contractions and pelvic pressure from organ distention
In what stage of labor does autonomic innervation of the visceral uterus senses pain from contractions and cervical dilation.
1st stage
In what stage of labor does somatic innervation of the vagina, vulva, and perineum sense pressure pain from the newborn passing through the birth canal
2nd stage
do narcotics cross the placenta
Yes, but only some cross the fetal blood-brain barrier
Fentanyl (an opiate) used for pain managment in pregnancy
- drug of choice bc of short half-life
- risks include include hypotension, nausea, vomiting, respiratory depression, depressed mental status, and decreased GI motility
- make sure resuscitation medication and equipment for the newborn should be readily available
Epidurals provide ___ not _____
provide analgesia NOT anethesia
risks of epidurals
- short-term backache
- puncture headache,
- hypotension,
- maternal fever,
- prolonged labor, and
- increased rate of instrumental delivery
Do epidurals increase a mother’s risk of delivering by cesarean?
no