Exam 2 pt2 Flashcards
The presence of bacteria in the bloodstream
-This can be a transient, self-limited phenomenon, cleared by immune system without event but can also progress to sepsis
bacteremia
*can seed other sites such as bone, lung, and meninges
Bacteremia coupled with inadequate perfusion and end-organ involvement
Meaning, decreased blood flow
Causing damage to important organs
sepsis
Sepsis which occurs in a neonate within the first 3 days of life
early-onset sepsis (EOS)
*Vertical transmission
Sepsis which occurs after the first 3 days until 2 to 3 months of life (definitions vary)
Late-onset (LOS)
*Horizontal transmission
sx:
- Temperature may be elevated or depressed. Recall that normal range is 36.5 to 37.5
- Tachypnea; ie, respiratory rate > 60/min
- Other signs of respiratory distress (retractions)
- Poor color (cyanosis, poor perfuson= mallor)
- Decreased responsiveness/lethargy
- Poor feeding
- Irritability or sleepiness
sepsis
Babies have a limited repertoire. Symptoms of ___ may be indistinguishable from non-infectious illness.
sepsis
mortality rate of EOS
15%
*Higher mortality in pre-term babies and Lower in full-term
what type of sepsis is even more likely to be complicated by meningitis with its attendant morbidity
late onset sepsis
Which bacterial organisms are involved with sepsis
- Group B Strep
- E. coli- actually #1 in preterm babies
- Other strep species, most commonly Pneumococcus
- Enterococcus (Group D strep)
- Staph (usually iatrogenic)
- Listeria
- Klebsiella
* These organisms all come from vagina or its neighbor, the GI tract
How does transmission of sepsis occur?
- During labor membranes rupture or become leaky
- Organisms can ascend from the birth canal (vagina)
- Fluid becomes infected, fetus inhales or swallows it and also becomes infected
if mom goes into labor early for no known reason think…
possible infection like sepsis (Premature babies are more vulnerable because of less adequate immune system)
*Very high risk for EOS
Also higher risk for mortality associated with sepsis
It may be that the premature labor was prompted by brewing infection
MAJOR RISK FACTORS of EOS
*Chorioamnionitis
Maternal Group B Strep carriage
Prolonged rupture of the membranes (18 hrs)
Prematurity
MINOR RISK FACTORS of EOS
Ethnicity (black women are at higher risk of GBS colonization)
Low socioeconomic status
Male sex
Low birth weight (>2500 grams)
Definition of Chorioamnionitis
Maternal temperature during labor > 38.o C or 1oo.4 F
And at least 2 other features
1. maternal leukocytosis- WBC > 15,000 in blood
2. maternal tachycardia- > 100 beats/min
3. fetal tachycardia- baseline > 160 beats/min
4. uterine tenderness (tenderness=elicited, pain=subjective)
5. foul smelling amniotic fluid
Gram positive bacteria
Carrier state in mother (in her normal flora)
GBS
*6-30% prevalence internationally
how is GBS transmitted
- Not sexually transmitted
- 50% vertical transmission
- Late onset disease is horizontal transmission
____% of babies born to mothers with GBS will develop early onset sepsis
1%
___% reduction in GBS sepsis from 1990s
87%
*Currently- all moms are cultured for GBS at 36 weeks and treat when they go into labor
risk factors for GBS
- Previous child who had early-onset GBS sepsis
- GBS bactiuria during current pregnancy
- Maternal fever/chorio
- Preterm labor
- We revert to these criteria now when GBS culture is not available
Definition of prolonged rupture
> 18 hrs
*The longer the membranes are ruptured, the higher the likelihood of ascending infection
definition of Prematurity
gestational age less than 37 yrs
sepsis workup includes
- Blood culture is mandatory (1-2ml from 1 site)
- Chest X-ray (almost always done)
- Lumbar puncture, aka “spinal tap” (look for WBC in CSF)
- Complete blood count (CBC)
- C-reactive protein
- Urine culture is NOT indicated in septic workup of a newborn in the first 3 days of life. It should be included in workup of late onset sepsis
blood culture of spesis characteristics
1-2ml
- Almost all pathogens will grow within 48hrs
- Positive blood culture is diagnostic of neonatal sepsis but negative culture does not rule it
When to include Spinal Tap for sepsis dx
- positive blood culture (Best performed before starting antibiotics, can be delayed if baby is unstable)
- sx referable to CNS (Neonates with symptoms of meningitis -TRUE lethargy, abnormal tone, excessive irritability, bulging fontanel, or septic shock)
- being proactive before starting antibiotics