PPS Flashcards

1
Q

What is meant by the ‘clinical iceberg’ of morbidity

A
  • Usually more unkown disease than known
  • Unkown tends to be milder, severe morbidities known
  • Because of this:
    • Amount of disease underestimated
    • Overall severity overestimated
      To assess the total amount of disease, need a survey of the wider population, not just those seeking care
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2
Q

What is epidemiology?

A

The study of the distribution and determinants of health and disease in human populations.

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3
Q

What is public health?

A

The science and art of:

  • prolonging life
  • preventing disease
  • promoting health

In the population, by the organised efforts of society.

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4
Q

How do epidemiology & clinical practice come together?

A

Clinical epidemiology.

The application of epidemiological methods in clinical practice informs understanding of:

  • Diagnosis
  • Causes
  • Consequences
  • Treatment
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5
Q

What is a prevalence rate?

A

The presence of disease new and old
- Has no time component. Epidemiologists dont view this as a true rate. Incidence & mortality rates are more informative as has time component.

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6
Q

What is an incidence rate?

A

Occurence of new cases of disease

No. new cases/at risk population (in specified time period)

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7
Q

What is the difference between disease rate & disease risk?

A
  • A disease rate expresses events/population
  • A disease risk is a statement of probabilty (a simple proportion)
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8
Q

What have migration studies shown, with respect to blood pressure? (origin = non western, adoption country = western)

A

Blood pressure patterns increase to match those of adopted population.

Evidence for mainly adult environmental influence on population BP

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9
Q

What does a cohort study show us?

A

Evidence of association between risk factors and outcomes. Allows us to look at relative & absolute disease risks by looking at a population over a long period of time

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10
Q

What is the healthy entrant effect?

A

Reduction in rates of morbidity and mortality in the initial stages of a longitudinal study in comparison with the general population because only healthy people were recruited to the study

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11
Q

What are some disadvantages of cohort studies?

A
  • Unkown risk factors (confounders)
  • Inference of association - not causation (participants are not randomised)
  • Bias from loss to follow up
  • Timely & expensive
  • Changes in participant behaviour & epidemiology of disease
  • Not suitable if disease is rare
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12
Q

What is meant by patient concordance?

A

(NICE 2007) - ‘the consultation process in which doctor and patient agree therapeutic decisions that incorporate their respective views, but now includes patient support in medicine taking as well as prescribing communication’

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13
Q

What are the two main sociological models of lay health beliefs? Briefly describe both

A

1) Health as functional capacity
- Idea of health as the ability to cope with everyday activities
- Working class conception of health
- Health is defined in the negative, includes notion of health as idea of ‘health despite disease’

2) Disease candidacy model
- Lay beliefs are constructed from appearance of a person, or the circumstances surrounding an event

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14
Q

What is the definition of a psychological theory of health?

What makes a good theory?

A

Definition - coherent account of phenomenon through influence & thought. Is empirically testable

Good theories:
- Explain related set of observations, not contradicted by observations.
- Testable hypothesis
- No more elements needed
- Comprehensible & coherent

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15
Q

What is the biopsychosocial model?

A

Holistic model that considers
- Presence of chronic illness
- Mental state
- Socioeconomic model

Contrasts the biomedical model

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16
Q

What are some pros & cons of quantitative vs qualitative data collection? (psychology)

A

Quantitative: objective, large cohorts.
+: quick, easy to compare data, cheaper
-: no depth, may be affected by bias

Qualitative: Subjective, smaller cohorts.
+: In-depth, generates lots of information about behaviour
-: Hard to standardise, time consuming, difficult to find participants

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17
Q

What is the COM-B model of behaviour change? (psychology)

Pros & cons?

A

Capability, motivation & opportunity all contribute to behaviour change.

Pros:
- Designs behaviour interventions
- Identifies components to be changed to meet targets

Cons:
- Doesn’t explain statistical behavioural variance
- Biased assumption that people are rational

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18
Q

What is the theory of planned behaviour?

Pros & cons?

A

Attitudes, subjective norms & percieved behavioural control feed into intention, which feeds into behaviour

Pros:
- Highlights social norms
- Intentions shown to predict some behaviour change (only 28%)

Cons:
- Past behaviour best predictor
- Environmental influences not considered
- Social support or habit not considered

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19
Q

What is the health belief model of behaviour change?

Pros & cons?

A

Expectancy-threat based model - weighing bad outcomes of behaviour against ability to act against it.

Modifying factors (age, gender, ethnicity, socioeconomics etc) lead into individual beliefs (perceived susceptibility, severity, benefits & barriers), which affect behaviour

Pros:
- Compares different influences on health behaviour
- Gives barriers

Cons:
- Threat doesn’t always predict behaviour change
- No emotions/habit/social norm modifications
- People underestimate liklihood of accidents
- No definition of how to test relationship between elements

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20
Q

What is the transtheoretical model of health behaviour change?

Pros & cons?

A

5-6 stages: precontemplation, preparation, action, maintenance, relapse.
Behaviour feeds into all of these.

Pros:
- Popular in practice
- Predicts some behaviour change
- Identifies broad processes leading to change

Cons:
- Stages vary between people
- Assumes change is planned
- No readiness to change
- Continuum of desire - no discreet changes in reality (oversimplification)

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21
Q

What is the cognitive dissonance theory?

A

Dissonance = difference between action & belief

Dissonance leads to change of belief, actions or change perception of actions, resulting in reduced dissonance

Pros: identifies theories & uses common sense

22
Q

What are three genetic causes of obesity? (theories)

A

Metabolic theory - low resting BMR is heritable

Fat cell theory - cell number genetically determined

Appetite theory - leptin regulates appetite

23
Q

What are the models of eating behaviour?

A

Developmental model
- Emphasis on learning
- Exposure reduces neophobia
- New associations form

Cognitive model:
Beliefs & values, theories of planned behaviour

Weight concern & body dissatisfaction:
“Screw it im already overweight, Ill eat the whole cake”

24
Q

What are the 4 main domains of professionalism?

A

1) Knowledge, skills & performance - reflect & keep records

2) Safety - follow regulations

3) Communication - avoid conflict, respect & cooperation

4) Maintain trust - treat all fairly, confidentiality, no plagiarism, admit mistakes

25
Q

What are the three types of reflective practices?

A
  1. Knowing in action - reflex
  2. Reflection in action - must adapt & think to meet a challenge
  3. Reflection on action - post-practice analysis
26
Q

What is consent & why do we need it?

A

What? - Pts voluntary agreement to treatment etc - waving right to bodily integrity. Consent shows respect for dignity & builds trust.

Why?
- Legal & professional requirement.
- Upholds autonomy, dignity & trust
- Provides full information allowing for informed choices

27
Q

What makes consent voluntary?

A
  • Pts able to refuse (& know they can)
  • Pts free from undue pressure (coercion & perceived coercion)
28
Q

What is needed for valid consent?

A

PARQCC
Procedure - nature of
Alternatives - informed of
Risks - informed of
Questions
Continuous
Capacity

29
Q

What are some issues with consent?

A
  • Consent cant be obtained without capacity
  • Time constraints
  • Complexity of information
  • Pts may decline to hear all information
30
Q

What are three approaches to assessing competency?

A

Subjective approach (GMC) - explain any risks to which the pt may attach significance

Hypothetical reasonable person approach - inform of a significant risk that would affect the judgement of a reasonable patient

Bolams test (1957) - prove you acted in the same way other HCPs would

31
Q

How do we determine competence?

A

Pt is competent if they can:
- Understand, retain & weigh up information relayed to them
- Communicate final decision

Pts can fluctuate between competent & not.

Avoid bias - ‘stupid’ decision does not equal not competent

32
Q

Why do we need confidentiality?

A
  • Legal right to privacy
  • Respect autonomy
  • Maintains trust

Using ethics:
- Virtue ethics
- Consequentialism
- Deontology (focus on principles)

33
Q

When are breaches of confidentiality appropriate?

A

Justifiable disclosure:
- Public interest & pt not competent/consent puts others at risk/consent undermines people/time necessity
- Real & serious risk of physical harm to identifiable individual

Statutory disclosure:
Legal duty have to uphold - must disclose certain things by law
(Notifiable diseases, births & deaths, drug addictions, court ordered…)

34
Q

What must be demonstrated to prove negligence in a civil suit?

A
  • Dr had duty to care (easy to prove)
  • Duty of care breached
  • Breach caused signficant harm
35
Q

What is the duty of candour?

A

Professional requirement of health providers to be open & transparent with those who use their services for treatment, especially if it goes wrong

36
Q

What is the four quadrants approach for medical intervention?

A

Indications for medical intervention (non-maleficence & beneficence)

Preferences of patient (autonomy)

Quality of life (beneficence)

Contextual features - religious, cultural & legal factors (justice)

37
Q

What are some theories of lay health beliefs?

A

1) Health as functional capacity:
- Health = ability to fulfill work & social roles
- Health = absence of disease
- Health in spite of disease

2) Disease candidacy model
- Developed to account for lack of engagement/compliance with health prevention strategies
- Retrospective assessment of disease candidates - judgements regarding individuals propensity for disease
- Illness/disease occurs due to a deeper purpose

38
Q

What is Zola’s model of health seeking behaviour?

A

Peoples response to symptoms depend on cultural values & beliefs concerning health.

First point of contact is to go to trusted individual to ask opinion.

5 x types of incident trigger the decision to seek medical care:
1. Interpersonal crisis
2. Perceived inteference with work
3. Perceived inteference with social/leisure activites
4. Sanctioning by others who insist help be sought
5. Symptoms persist beyond arbitrary time limit set by inidividual

39
Q

What are the differences between experimental & observational clinical studies?

A

Experimental (RCT)- researcher controls exposure of interest

Observational (cohort)- exposure of interest is observed.

Random allocation occurs in experimental study, not observational

40
Q

What are the main types of systematic bias that can occur in RCTs?

A

Selection bias - study sample not representative of population of interest

Allocation bias - bias in who receives treatment, e.g. without randomisation, given to sicker pts etc. This also increases confounding

Ascertainment/information bias - bias in measuring/classification of outcomes based on knowledge of treatment arm. Can be response or assessor bias (blinding prevents this)

Analytic bias - bias in analysing data

41
Q

What is a cohort study?

What is a prospective & retrospective cohort study?

A

Cohort study - investigator selects a disease-free (outcome free) cohort of exposed & non-exposed individuals & follows up both groups to compare incidence of disease (or rate of death from disease)
Outcomes give RR, AR & absolute risk

Prospective - exposure & non exposure are ascertained as they occur during study

Retrospective - exposure ascertained from past records, outcome ascertained at time of study

42
Q

What are some advantages of cohort studies?

A
  • Population sampling is possible
  • Can investigate toxic or carcinogenic agents (would be unethical in RCT)
  • Can establish temporal relationship of exposure & disease
  • Convenient for rare exposure (not outcome, which is a disadvantage)
  • Can study associations of an exposure with multiple diseases
43
Q

What are some key pitfalls & their solutions of geographical studies?

A
  • Differences in ascertainment between countries (population-wide survey with objective measures)
  • Differences in diagnosis/recording between countries (standardise diagnostic criteria (WHO)
  • Differences in population structure (take age & gender into account)
44
Q

What is a case-control study?

A

Case of disease occurs, look back to see if person was exposed or not, with a control group to compare against.

Must select case of diease with standard definition of the disease

45
Q

How should confounding & bias be dealt with in case control studies?

A

Confounding:
- Match each case & control with similar confounding factors (i.e. two 60yo Males).
- Complete study at same level of confounder (i.e. all smokers/non-smokers)
- Manage at analysis stage

Bias:
- Information bias - ensure information on exposure is obtained from cases & controls in same way
- Selection bias - select cases & controls from similar population

46
Q

What studies can be done to identify causal factors of a disease?

A

Case control, longitudinal (cohort), and RCT

47
Q

What is the Bradford Hill criteria?

A

Guidelines used to assess if an association is causal.

Strong - high RR
Independent - not result of a confounding factor
Dose response - higher exposure = higher risk
Temporal sequence - first exposure, then outcome
Consistent - different studies have similar results
Specific - one exposure, one outcome
Reversible
Biological plasuability
Analogy - parallels with other established disease models

48
Q

What are some strengths & weaknesses of a high risk prevention strategy?

A

Strengths:
- Likely to be effective & cost effective
- Can offer intervention appropriate to individual
- Motivation of pt & Dr usually high
- Avoids interference with low risk groups

Weaknesses:
- Involves screening, imperfect process with its own costs & risks
- Not a radical approach, limited effect on whole population & incidence
- Singling out, medicalising & labelling pts as abnormal

49
Q

What are some pros & cons to RCTs?

A

Pros:
- RCTs can exclude possibility of confounding & bias
- Wide range of possible study topics (surgical, pharm, health promotion)

Cons:
- More difficult to assess long term interventions & lifestyle changes

50
Q

Why are control groups important?

A

Compare new treatment to control, to assess effectiveness.

Cant just study intervention as pts tend to get better anyway:
- Regression to mean
- Natural tendency to recover
- Placebo effect