Life Maintenance Flashcards
List some water soluble micronutrients?
Vitamins B & C
What are vitamins used for specifically?
Used as cofactors in metabolism
List some fat soluble micronutrients
Vits ADEK
How do we calculate total energy expenditure?
Total energy expenditure = BMR + diet induced thermogenesis + activity +/- stress (illness/inflammation/surgery)
TEE = BMR + DIT + activity (+stress)
Why do we not use ferritin alone to determine Fe deficiency?
Is also an acute phase protein, so concentrations increase during inflammation
This is why we use iron binding studies & do not just rely on one test
What are direct & indirect calorimetry?
Direct - measure heat produced by person in sealed chamber
Indirect - estimates heat production by comparing O2 & CO2
What things affect nutrient requirements?
Age, gender, body size, level of physical activity, state of health, physiological status (pregnancy & lactation), growth
What are the different dietary reference values?
Estimated avg requirement (EAR)
Reference nutrient intake (RNI)
Lower reference nutrient intake (LRNI)
Safe intake (SI)
LRNI & RNI are two SDs from mean in either diection
What is EAR (nutrition)?
ESTIMATED AVG REQUIREME
- An estimate of average requirement for energy, or a nutrient
- Approximately 50% of the population will need less & 50% will need more
- EAR is used for energy
What is RNI (nutrition)?
Recommended nutrient intake
- Amount of a nutrient that is enough to ensure that needs of nearly all population (97.5%, 2 x standard deviations) are being met
- Many within the group will need less
- Only 2.5% of group will need more
- Often used as a reference amoutn for population groups
- Used for protein, vitamins & minerals
What are some issues with dietary reference values?
- Bioavailability
- DRVs do take standard (usually low) bioavailability into account, but other things can affect it, e.g. tannin in tea inhibits Fe absorption
- Assumes that requirements for other nutrients are met
- Differences in DRVs between countries
- Based on best available evidence
- Reflect needs of healthy people only
What are the general causes of nutrient deficiencies, with examples?
- Inadequate intake
- E.g. Reduced appetite, poor availability of food
- Reduced absorption
- E.g. Coeliac disease
- Increased losses
- E.g. diarrhoea, vomiting
- Increased demand
- E.g. growth, pregnancy
What occurs in severe vitamin A deficiency?
Increased risk of infection, xeropthalmia (blinding or non blinding)
Where are cardbohydrates and protein absorbed in the GI tract?
Carbohydrates & protein absorption mostly in duodenum & jejunum
Where are fats absorbed in the GI tract?
Ileum - fat absorption bound to bile, & fat-soluble minerals
Where in the GI system is vitamin B12 absorbed?
In the terminal ileum, bound ti intrinsic factor
Where in the GI system are fluids & potassium absorbed?
Ileum & colon
What is the basic structure of the GI tract?
Oesophagus - Stomach - Duodenum - Jejunum - Ileum - large intestine - colon
List the main roles of the liver
Synthesis, composition & excretion of bile
Synthesis of clotting factors & their actions
Plasma protein production
Metabolism & excretion of bilirubin
Metabolism of carbohydrates, fats, & nitrogen
Drug metabolism
Detoxification
What are the two main types of cell in the liver, and their functions?
Hepatocytes (60%) - perform most metabolic functions
Kupffer cells - type of tissue macrophage, clears gut-derived endotoxins from blood
Outline the hepatic lobule
Hepatic lobule = functional unit of the liver.
Hexagonal plate of hepatocytes around central hepatic vein.
At each of 6x corners is triad of branches - portal vein, hepatic artery and bile duct (bile duct travels outwards)
https://www.notion.so/Overview-of-the-liver-87a2210eed8b4f9aa3b1c3c9b12da349#aca6502028214d599782ac5de1af5abc
What are the functions of bile?
Emulsifies fats to allow absorption
Neutralises gastric juice in S intestine
Eliminates waste products from blood (esp bilirubin & cholesterol)
Outline how bile is secreted
- Hepatocytes secrete bile salts, cholesterol & others
- Epithelial cells lining bile ducts secrete watery solution of Na & HCO3
(Stimulated by hormone secretin in response to acid in duodenum)
How is bile synthesised?
The liver synthesises primary bile acids from cholesterol. Then p.acids conjugated with glycine & taurine (3:1) = bile salts
Bile salts transported against concentration gradient from sinusoidal blood into bile canniculae