PPP from handout

Question 1

Pentose phosphate pathway serves as an alternative route for ___________.

Answer 1

Glucose Oxidation

Question 2

The Pentose Phosphate pathway occur in what location of the cell?

Answer 2

Cytosol

Question 3

The pentose phosphate pathway is active in which areas?

Answer 3

Liver
Adipose Tissue
Lactating mammary gland
Adrenal Cortex
RBC

Question 4

What are the functions of Pentose Phosphate pathway?

Answer 4

Source:
1. NADPH + H+
2. PENTOSES

Question 5

Use of NADPH+ given by the pentose phosphate pathway

Answer 5

REDUCTIVE BIOSYNTHETIC PROCESSES

Synthesis of cholesterol, fatty acids, steroid hormones

Question 6

Use of pentoses given by the pentose phosphate pathway

Answer 6

For nucleotides

Nucleic acids, coenzymes

Question 7

Describe ATP in Pentose Phosphate Pathway

Answer 7

Neither consumed nor produced

Question 8

How Glycolysis and HMP shunt are interconnected?

Answer 8

HMP shunt branches off glycolysis at G6P

Question 9

What connects/links HMP shunt and glycolysis?

Answer 9

Transketolase and Transaldolase

Question 10

How do enzymes of HMP shunt re-enters or re-route to glycolysis?

Answer 10

In the form of F-6-P

Question 11

What is utilized during oxidation in PPP, compared to that of Glycolysis?

Answer 11

Glycolysis - NAD used

PPP - NADP used

Question 12

How many moles of NADPH are form per mole of glucose-6-P during the conversion of Glucose-6-P to 6-Phosphogluconolactone?

Answer 12

2

Question 13

Why is NADPH used instead of NADH in reductive reactions that require electrons?

Answer 13

because NADPH:NADP ratio is greater that NADH:NAD

[ensures that these pathways have sufficient electron donors to support the synthesis of complex molecules]

Question 14

How is the Non-oxidative phase of the PPP reversible?

Answer 14

Allows GA3P and F-6-P be converted back into a 5C sugar

Question 15

The fate of the enzymes in non-oxidative phase is dependeint on __________.

Answer 15

Needs of the cell