Power Points Flashcards
Symptomatics
things we can see
Asymptomatics
things we can not see
Diseases
Impairment of normal state (homeostasis) of the living animal or plant body or component thereof
What is the leading killer of humans?
mosquitos
Who is the father of medicine?
Hippocrates
What are the four humors of life?
blood
phlegm
yellow bile
black bile
Most common way ancient people treated disease?
Blood letting
Which civilization began to take public health measures?
Rome
The Renaissance brought what idea to replace the humoral theory?
contagion
Who came up with the idea of vaccination?
Edward Jenner
Louis Pasteur
pasteurization
Koch’s postulates for linking agent to a disease
- organism must be present in a disease
- can be grow in culture
- cause disease when injected into a healthy animal
- Can be recovered from newly diseased animal
Joseph Lister
use of antiseptic procedures
What is the current disease causation theory?
multiple causation
Epidemiology
observation of occurrence of disease in populations
Hyperferritinema
too much iron in the blood (blood letting is treatment)
Morbidity
a diseased state or symptom
Nosocomial Infections
infections contracted from hospital stays
Inductive Reasoning
goes from the specific to the general
Deductive Reasoning
reasoning which constructs or evaluates deductive arguments. Deductive arguments are attempts to show that a conclusion necessarily follows from a set of premises
Antibiotic
resistance threat
CDC
The U.S. Government’s lead public health agency
-itis
swelling
-iasis
infested with
-ology
the study of
Epidemiology
is the study of the determinants, occurrence, and distribution of health and disease in a defined population
Infection
the movement into and replication of organisms in host tissue(s), which may (or may not!) cause disease
Carrier
an individual with no overt disease who harbors infectious organisms
Dissemination
the spread of the organism in the environment
Chain of Infection
- etiologic agent
- the method of transmission in the environment (by contact, by a common vehicle, or via air or a vector)
- host
Disease Reservoirs
the place in nature (if known, an organism or even a tissue within an organism) where a disease NORMALLY LIVES or is found in significant numbers
Zoonose Reservoirs
Diseases “reserved” in animals
Inanimate Reservoirs
secondary or accidental reservoirs (doorknob)
Disease Transmission
- Direct contact (from person-to-person or reservoir-to-person)
- Fomites/Indirect Contact (spread from an inanimate object called a fomite)
- Vectors (spread by arthropods)
- Carriers (can be chronic or Transient)
Leukocytes
(white blood cells) specific to the innate immune system
Phagocytosis
type of leukocyte; process by which leukocytes ingest microorganisms
Neutrophils
type of leukocyte; ingest microbes then die, many dead ones form pus
Macrophages
type of leukocyte; can kill many microbes, can detect and destroy rouge cancer cells
Natural Killer Cells
type of leukocyte; Identify infected cells by presence of MHC1, bind with infected cells and excrete enzymes to destroy its membrane
Dendritic Cells
type of leukocyte; consume pathogens and relay information about them to spleen or liver (connects innate and adaptive immune systems)
Antibodies
Y-shaped protein used to identify and neutralize antigens
B-cells
ells that produces antibodies and mature in the bone marrow
T-cells
produces antibodies
Humoral Response
antibody mediated response
Cell-Mediated Response
does not involve antibodies, but rather involves the activation of phagocytes
How are pathogens remembered/recognized?
- Dendritic Cell Communication
- B-Cells and T-Cells activated
- Antibodies travel through bloodstream
- Antibodies bind to antigens
- Gather information and Somatic Hypermutation
- Become Memory B and T Cells
Active Immunization
primary or secondary immune response
Passive Immunization
protection by a mother during pregnancy
What are the 7 NTDs hilighted in the END7 campaign?
- Whipworm
- Hookworm
- Roundworm
- Elephantiasis
- River Blindness
- Snail Fever
- Trachoma
What disease are ballet dancers likely to get due to their lack of exposure to the sun (and therefore lack of Vitamin D)?
rickets
Six stages of diseases
- Incubation
- Prodrome
- Clinical
- Decline
- Convalescent
Normal Flora
Microorganisms that normally reside at a given site and under normal circumstances do not cause disease (bacteria in your stomach)
Microbial Antagonism
belief that normal flora benefit a host by preventing overgrowth of more harmful bacteria
Symbiosis
close relationship between two organisms
Commensalism
a relationship in which one organism benefits and the other is unaffected
Mutualism
a relationship in which both organisms benefits
Parasitism
a relationship in which one organism benefits and the other is harmed
Opportunism
organisms don’t cause disease unless appropriate condition exists
Edema
a fluid collection under the skin
Inflammation
reaction to injury
Four steps in the process of inflammation
- Vasodilation- leads to greater blood flow to the area, causing redness and heat
- Vascular permeability- cells lining the vessels become “leaky” either from cell injury or chemical mediators
- Exudation- fluid, proteins, red blood cells, and white blood cells escape from the intravascular space
- Vascular Stasis- slowing of blood in the bloodstream to allow chemical mediators and inflammatory cells to collect and respond to stimulus
Acute Inflammation
marked by an increase in inflammatory cells
Watch these on Wednesday night
https: //www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/inflammatory-response
https: //www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/types-of-immune-responses-innate-and-adaptive-humoral-vs-cell-mediated
https: //www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/how-white-blood-cells-move-around
https: //www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/role-of-phagocytes-in-innate-or-nonspecific-immunity
Chemokines
chemical signals that are responsible for attracting white blood cells to infection
Two main cells of the adaptive immune system
(lymphocytes)T cells and B cells
Antigen
foreign material that could potentially cause disease
What cells produce antibodies?
B Cells (but only after they are activated by T cells