Post Transplant Infections

Question 1

Medication for Pneumocystitis and Toxoplasma prophylaxis

Answer 1

Bactrim

Question 2

Prophylaxis for CMV should be given with:

Answer 2

Valganciclovir

Prophylaxis with valgancyclovir is appropriate for solid organ donors at risk for or with known CMV infection

prophylaxis is not necessary if both donor and recipient are negative

Question 3

Which antiviral is preferred for prophylaxis for patients with HSCT?

Answer 3

acyclovir to avoid myelosuppression

Question 4

How do you treat CMV in posttransplant patients?

Answer 4

• immunosuppressive therapy may need to be reduced
• IV ganiciclovir
• oral valganciclovir
• oral foscarnet
• IV cidofovir

Question 5

Which virus is found in almost all patients with lymphoproliferative disease

Answer 5

EBV

Question 6

CMV is associated with what clinical features

Answer 6

An increased risk for renal graft failure
GI perforation and significant bleeding
CMV related PNA and respiratory failure
EBV, Polyomavirus BK, Polyomavirus JC and Hepatitis B/C reactivation