post-translational modifications Flashcards

1
Q

list three ways a protein could be modified post-translationally (there are 9)

A
  1. methylation
  2. ubiquidation
  3. phosphorylation
  4. acetylation
  5. SUMOylation
  6. lipidation
  7. hydroxylation
  8. glycosylation
  9. disulfide bond
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2
Q

list 2 reasons why glycosylation could be important for a protein’s function

A
  • carbohydrates are hydrophilic so they change the polarity and solubility
  • serve as markers for protein to get to its cellular destination
  • structural complexity forms a code
  • facilitate cell-cell interactions
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3
Q

what is one reason why lipidation could be important for a protein’s function?

A
  • allows proteins to anchor in the membrane
  • involved in cellular signal transduction
  • helps in protein-protein interaction
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4
Q

what is the most common function of ubiquidation?

A
  • labeling proteins for proteasomal degradation
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5
Q

what is a signal sequence?

A
  • direct proteins to their cellular destination
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6
Q

what is an example of a type of signal sequence that would not be cleaved?

A

Nuclear localization sequences (NLS) are not cleaved

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7
Q

preprotein

A
  • protein precursor that contains a signal peptide sequence that is cleaved
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