Post Partum Care Flashcards
Brexanolone is
Allopregnanolone
Given IV
Modulator of GABA-a receptors
Used to treat postnatal depression
Zuranolone is
Allopregnanolone
Neuroactive steroid
GABA-A receptor modulator
Pain management after c/s
Intrathecal diamorphine max 300 mcg or 3mg via epidural OR
Intrathecal morphine 100mcg + 15mcg fentanyl or 3mg morphine via epidural
Oral morphine sulfate, paracetamol and ibuprofen +/- dihydrocodeine
Tramadol or oxycodone if not sufficient
C/S wound care
Negative pressure wound therapy if BMI >35
Remove dressing 6 to 24 hours after
Risk of stress incontinence after c/s
4%
PPH target parameters
Hb >80 g/l
Plts >50 x 10(9)/l
PT and APTT <1.5 x normal
Fib > 2g/l
Use of FFP in PPH
1 unit for every 4 units RBC (15ml/kg) if PPH ongoing
> 15ml/kg if PT/APPT >1.5 x normal
Use immediately after thawing
Incidence of primary minor PPH
18% deliveries
Incidence of primary major PPH
1-5%
Define secondary PPH
Excessive vaginal bleeding 24h to 12 weeks postpartum
Incidence of secondary PPH in high income countries
0.47 - 1.44%
Active management of third stage reduces PPH by
RR 0.34
66%
Prevention of PPH for women without risk factors
Oxytocin 10 units IM for SVD
5 units slow IV for c/s
Prevention of primary PPH in women with risk factors
Syntometrine for SVD
Oxytocin + consider TXA for C/S
MDT for major PPH
Midwife in charge
Band 6 midwife
Obs reg
Anaesthetic reg
On call clinical haematologist
Porters
Alert consultant obstetrician, anaesthetist and blood lab
Resuscitation for minor PPH without shock
IV access
FBC, coag, G&S
HR, RR, BP every 15 mins
Warmed crystalloid infusion
Resuscitation for major PPH with ongoing bleeding or signs of shock
Assess airway
Start 15L oxygen
Continuous HR, RR, BP (use ECG)
Temp every 15 minutes
2 x cannulae
Cross match 4 units, FBC, coag, U&E, LFT
Keep warm and lie flat
Give blood if signs of shock or Hb <70 with ongoing bleeding
Give 2L warm crystalloid then 1.5L warm colloid pending blood
Catheter
HDU/ICU care
Consider art line
Use of cryoprecipitate
2 pools if fib <2 g/L
If no clotting result then: 2 pools cryo + 1 platelet for every 8 units RBC
Dose of syntometrine
5 units oxytocin
500 micrograms ergometrine
Dose carboprost
250 micrograms repeated every 15 minutes up to 2mg (8 x doses)
Side effects of carboprost
Bronchospams
Hypertension
Vasodilation
Increased risk infection
Dose of misoprostol
800 micrograms SUBLINGUAL
(Can be oral or rectal)
Oxytocin dose for fluid restricted women
30 units in 26 crystalloid
10ml/hr through syringe driver
Surgical management of PPH
1st line - balloon tamponade
2nd line - brace suture
3rd line vascular ligation
4th line - hysterectomy
Incidence of retained placenta
3%
Risk of secondary PPH after retained placenta
1-2%
Occurs 8-14 days later due to sloughing of placental site
Placement of brace suture
3cm above and below incision line
Effectiveness of brace suture
75% prevention hysterectomy
Stepwise uterine devasculariation
One uterine artery, then both
One ovarian artery, then both
Effectiveness of stepwise uterine devascularisation
100% avoidance hysterectomy
Internal iliac artery ligation risks
Ureteric injury
Success of internal iliac artery ligation
61% avoidance of hysterectomy
Effectiveness of Selective arterial occlusion (interventional radiology)
86.5% arrested bleeding
Protamine sulphate is used for ____
Reversal of unfractionated heparin or LMWH (partial effect)
Side effects of protamine sulphate
Bronchospasm
Anaphylaxis
Protamine sulphate protocol
5mg/min for 5 minutes
Max dose 50mg over 10 minutes
Management of women who decline blood products
Advanced directive
Counsel without partner/family
Active 3rd stage
Consider cell salvage for both c/s and SVD
Prophylactic interventional radiology on high risk (PAS)
Consider alternatives (inc EPO)
Causes of secondary PPH
Endometritis
RPOC
Abnormal involution of placental site
Pseudoanuerysms and AV malformation
How many secondary PPHs present with massive haemorrhage?
10%
When does secondary PPH present
19% in first 7 days
41% day 8-14
23% days 15-21
12% days 22-28
Risk of uterine perforation with SEVAC postpartum
1.5%
Commonest organism causing c/s wound infection
Staph aureus
Risk of nec fash after c/s
1.8 in 1000