Post-Operative Nausea and Vomiting Flashcards
1
Q
Dopamine antagonists used for post-op nausea/ vomiting
A
Droperidol and Metoclopramide
2
Q
What drug class does Droperidole belong to?
A
Dopamine antagonists.
3
Q
How are 5HT3 antagonists used for PONV?
A
Given at the end of surgery. More effective against vomiting than nausea.
4
Q
Why wouldn’t you prescribe Pethidine?
A
Strongly discouraged because of:
- short duration of action,
- accumulation of the toxic metabolite norpethidine which may result in seizures,
- high propensity for inducing drug-seeking behavior.
5
Q
Why wouldn’t you use metoclopramide or droperidol to treat a patient with parkinson’s disease?
A
Dopamine antagonists - dopamine involved in pathogenesis of Parkinson’s disease.
6
Q
In which cohort of patients is codeine ineffective?
A
CYP2D6 ‘poor metaboliser’ patients.
