Post-implantation development Flashcards

1
Q

Describe invasive implantation

A

trophectodermal cells breaking through endometrium and invading into the underlying stroma
- decidualization

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2
Q

differences between invasive and non-invasive implantation

A

invasive consists of decidualization

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3
Q

outline non-invasive implantation

A

blastocyst come into contact with endometrium - apposition
trophectoderm multiply and invading in the endometrial tissues - adhesion
trophoblasts grow into villi and and with blood vessels form the placenta

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4
Q

what maintains progesterone production

A

human chorionic gonadotrophin secreted by syntiotrophoblasts of embryo and placenta

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5
Q

name the two types of diapause

A

obligatory diapause and facultative diapause

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6
Q

what do polar TE give rise to

A

ectoplacental core and extraembryonic ectoderm

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7
Q

what do mural TE give rise to

A

trophoblast giant cells

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8
Q

function of trophoblast giant cells

A

invade uterine wall and modify maternal blood vessels preparing them to perfuse placenta

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9
Q

why do cytotrophoblast cells block spiral arteries

A

allow embryo to develop in low oxygen environment and reduce risk of free radicals

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10
Q

Name 5 functions of placenta

A
  • connects fetus to mother
  • transfer nutrients from maternal blood supply to fetus and waste products away
  • keep two blood supplies separate
  • immune system is down-regulated
  • synthesize biologically active molecules
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11
Q

function of yolk sac

A

provide nutritional support

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12
Q

what forms the yolk sac

A

primitive endoderm and between visceral endoderm n parietal endoderm in mouse

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13
Q

what is different in fetal membranes in mouse n human

A

outermost layer in mouse is derived from parietal yolk sac (parietal endoderm) and human is chorion (mainly cytotrophoblast cells)

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14
Q

what is the function of fetal membranes

A

retain amniotic fluid around embryo, paracrine regulators of amnion, chorion and decidua

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15
Q

describe the human embryonic development

A

formation of bilayer disc (epiblast and hypoblast), axis formation, gastrulation and organogenesis

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16
Q

where to derive trophoblast stem cells

A

compartment of extraembryonic ectoderm of post implantation embryo

17
Q

what can TS differentiate into

A

trophoblast giant cells

18
Q

where to derive extraembryonic endoderm stem cells

A

primitive endoderm

19
Q

what do XES mainly contribute to

A

parietal endoderm

20
Q

what is specification of cell commitment

A

the fate of a cell to be specified when it is capable of differentiating autonomously , can be reversed

21
Q

what is determination of cell commitment

A

cell is determined when it is capable of differentiating autonomously even when placed in another region, irreversible

22
Q

what is primed pluripotency

A

they have advanced developmentally