Cell potential and self-renewal Flashcards
What is cell potency
the range of commitment options available to a cell
Name the three compounds that make up the blastocyst
trophectoderm, epiblast, primitive endoderm
describe the stages from a zygote to blastocyst
fusion of gametes to form zygote, cleavage of cells to form blastomeres, more cleavage to form morula, Cells on the outside form trophectoderm layer and inside form inner cell mass and segregate into epiblast and primitive endoderm
which potency can produce a fully functional organism
totipotent
which potency can only differentiate into one cell type
unipotent
which potency can produce all body’s cell lineage, including germ cells and all extraembryonic cell types
pluripotent
which potency can form mulitple lineages that constitute an entire tissue
multipotent
which potency can differentiate into all three germ layers
pluripotent
which is the potency of most adult stem cells
mulitpotent
potency of spermatogonial sc
unipotent
how to show a cell is multipotent
inject a single cell and show it can make all blood lineages
how to show a cell is multipotent and can self-renew
do a secondary single cell transplant to prove the first cell injected can make perfect copies of itself and also can make all blood lineages