Post-Class Dermatopathology

Question 1

what are the two main disease associations of erythema nodosum?

Answer 1

1. sarcoidosis
2. inflammatory bowl disease
3. malignancy

Question 2

what are the histologic features of leukocytoclastic vasculitis?

Answer 2

leukocytoclasia is fragmentation of the neutrophils so you’ll see fragmented pins in the vessel walls and damage to the vessel walls

Question 3

what is the Koebner phenomenon? which two diseases are associated with it?

Answer 3

lesions in other areas due to injury or trauma

1. psoriasis
2. lichen planus

Question 4

what are the two types of abnormal elastic fibers?

Answer 4

1. senile (due to age)

2. actinic (due to UV damage)

Question 5

if you have suprabasilar vesicle, with antibodies to desmoglein 3, intercellular IgG and a Nikolsky sign. what is this?

Answer 5

pemphigus vulgaris

Question 6

if you have a subepidermal blister, antibodies to hemidesmosomes, linear IgG and C3 at the DE junction and tense blisters. what do you have?

Answer 6

boullous pemphigoid

Question 7

what if you have celiac disease, vesicles on extensor surfaces and IgA at tips of dermal papilla

Answer 7

dermatitis herpetiformis

Question 8

morphea is also called….

Answer 8

limited scleroderma

Question 9

what is the antibody associated with primary systemic sclerosis?

Answer 9

SCL70

Question 10

what is the most common type of panniculitis?

Answer 10

erythema nodosum

Question 11

what is acanthosis?

Answer 11

increased thickening of epidermis

Question 12

what is spongiosis?

Answer 12

edema around the cells of the epidermis = intercellular edema

Question 13

what is wheal associated with which disease?

Answer 13

urticaria

Question 14

target lesions and infections like mycoplasma/HSV are associated with what disease?

Answer 14

erythema multiforme

Question 15

granular IgG and C3 deposited and the DE junction are associated with which 2 conditions?

Answer 15

1. SLE

2. discoid lupus

Question 16

Civatte bodies are associated with which disease?

Answer 16

lichen planus

Question 17

pigment incontinence is associated with which 2 diseases?

Answer 17

1. lichen planus

2. lupus erythematosus

Question 18

Munro’s micro abscesses are associated with which disease?

Answer 18

psoriasis

Question 19

Auspitz sign is associated with which disease?

Answer 19

psoriasis

Question 20

Breslow thickness is….

Answer 20

melanoma

it is the MOST important prognostic factor

Question 21

ABCDE of melanoma?

Answer 21

Assymetry

Border irregularity

Color variegation

Diagmet > 6 mm

Evolution

Question 22

permethrin is used to treat what?

Answer 22

scabies

Question 23

strep or staph + honey color crust + subcorneal vesicle =

Answer 23

impetigo

Question 24

malassezia furor causes?

Answer 24

tinea versicolor

Question 25

what are furrows in relation the skin?

Answer 25

linear streaks

related to scabies

Question 26

sandpaper texture is related to what lesion?

Answer 26

actinic keratosis

Question 27

Bowen’s disease is also called?

Answer 27

squamous cell carcinoma in situ

Question 28

peripheral palisading is related to what disease?

Answer 28

basal cell carcinoma

Question 29

HHV8 virus is related to which skin condition?

Answer 29

Kaposi sarcoma

Question 30

Pautrier microabscess is related to?

Answer 30

mycosis fungoides

Question 31

what is Sezary syndrome?

Answer 31

1. blood involvement by mycosis fungoides

2. lymphocytes with cerebriform nuclei

Question 32

HPV 2 and 4

Answer 32

verruca vulgaris

Question 33

HPV 6 and 11

Answer 33

condyloma acuminata; low risk

Question 34

VZV lesions look like what

Answer 34

vesicle on an erythematous base

Question 35

what do shingles lesions look like?

Answer 35

it’s a reactivation of dormant chickenpox in the dorsal root ganglion

dermatomal rash that is very painful

Question 36

mollusk contagiosum

Answer 36

grouped umbilicate papules

they have a cytopathic effect that leads to cell death and proliferation