Population Genetics

Question 1

What does polymorphic mean?

Answer 1

allelic variants present in more than one percent of the population

Question 2

How do consanguineous matings change the gene pool?

Answer 2

increase in homozygote frequency

Question 3

What does linkage disequilibrium mean?

Answer 3

non-random association of alleles at two or more loci

Question 4

In X-linked recessive diseases, what is the allele frequency?

Answer 4

fraction of the males who are affected

Question 5

CFTR heterozygotes carry a protection against?

Answer 5

typhoid

Question 6

Sickle cell anemia carry a protection against?

Answer 6

malaria

Question 7

beta-thalassemia carry a protection against?

Answer 7

malaria

Question 8

Hemochromatosis carry a protection against?

Answer 8

Plague

Question 9

What is assortative mating?

Answer 9

selection of partners based on specific genetic traits

Question 10

Old Order Amish of Lancaster county are susceptible to?

Answer 10

ellis van Creveld disease

Question 11

Ashkenazi jews are susceptible to?

Answer 11

tay sachs

Question 12

French Canadians are susceptible to?

Answer 12

tyrosinemia

Question 13

What does linkage mean?

Answer 13

meiotic recombination between two markers is somewhat unlikely

Question 14

What is linkage disequilibrium?

Answer 14

recombination of two markers is found more frequently than predicted

Question 15

Linkage disequilibrium between a disease allele and a nearby allele is only observed when?

Answer 15

the disease causing mutation was introduced into the population relatively recently