Molecular Medicine II

Question 1

To be cured by gene therapy, what must the target gene be?

Answer 1

recessive

Question 2

Somatic gene therapy targets what type of cells?

Answer 2

somatic

Question 3

What was the first disease to be ‘cured’ by gene therapy? What caused this disease?

Answer 3

SCID

defective adenine deaminase

Question 4

What does in vivo gene therapy aim to do?

Answer 4

aims at treating cells directly in the patient

Question 5

ERBB2 encodes what?

Answer 5

EGFR

Question 6

What two facets contribute to a viral delivery system?

Answer 6

aggressive spread and integration

Question 7

What does ADA breakdown?

Answer 7

deoxyadenosine

Question 8

How does indirect detection function?

Answer 8

follow a marker associated with a disease

Question 9

What is a copy number variation (CNV)?

Answer 9

insertion or deletion of chromosomal region

Question 10

How are CNVs detected?

Answer 10

comparative genome hybridization and FISH

Question 11

How does comparative genome hybridization become evident?

Answer 11

uneven labeling of template DNA

Question 12

What does warfarin inhibit?

Answer 12

vitamin K epoxide reductase

Question 13

A polymorphism in what gene can affect warfarin dosaging?

Answer 13

VKORC1

Question 14

What cytochrome enzyme degrades warfarin?

Answer 14

CYP 2C9