Population genetics #13 Flashcards

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1
Q

population genetics

A

is the study of genetic variation in a pop. with implications for pop. evolution

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2
Q

what are the 2 approaches for studying pop.

A

~descriptive approach

~statistical approach

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3
Q

a pop is characterized by a - and their associated -

A

a pool of genes

phenotype

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4
Q

how to calculate the phenotypic frequency

A

of individuals with a specific phenotype / total # of people

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5
Q

how to calculate genotypic frequency

A

of individuals with a specific genotype / total # of people

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6
Q

how to calculate allelic frequency

A

of alleles of a certain type / total #of alleles

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7
Q

genotypic frequencies are

A

p^2, 2pq, q^2

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8
Q

Hardy weinburg works if

A
~pop size is infinite
~no immigration or emigration
~random mating
~no mutation
~no selection
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9
Q

x^2 calculates what?

A

the probability distribution of variables whose sum is not independent from each other, if the P value <0.05 there is a violation of the rules

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10
Q

genetic drift

A

random changes in the frequency of alleles in a gene pool, affects smaller pop. more

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11
Q

founder effect

A

when few individuals from a pop. start a new pop.

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12
Q

bottle necks can result from

A

catastrophic events

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13
Q

selection

A

is the preferential survival of individuals with certain genotypes by means of natural factors

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14
Q

what 3 things are needed for natural selection to happen

A

~variation among individuals
~number of offspring are different
~variation must be genetically inherited

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15
Q

what 4 diseases are advantages to be heterozygous of?

A

sickle cell anemia, cystic fibrosis (against TB and diarrhea), triosephosphate isomerase deficiency (against oxidative stress), diffuse presence of the HLA-DRB1 allele(against HCV infection progression to end stage liver disease)

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