Population genetics #13 Flashcards
population genetics
is the study of genetic variation in a pop. with implications for pop. evolution
what are the 2 approaches for studying pop.
~descriptive approach
~statistical approach
a pop is characterized by a - and their associated -
a pool of genes
phenotype
how to calculate the phenotypic frequency
of individuals with a specific phenotype / total # of people
how to calculate genotypic frequency
of individuals with a specific genotype / total # of people
how to calculate allelic frequency
of alleles of a certain type / total #of alleles
genotypic frequencies are
p^2, 2pq, q^2
Hardy weinburg works if
~pop size is infinite ~no immigration or emigration ~random mating ~no mutation ~no selection
x^2 calculates what?
the probability distribution of variables whose sum is not independent from each other, if the P value <0.05 there is a violation of the rules
genetic drift
random changes in the frequency of alleles in a gene pool, affects smaller pop. more
founder effect
when few individuals from a pop. start a new pop.
bottle necks can result from
catastrophic events
selection
is the preferential survival of individuals with certain genotypes by means of natural factors
what 3 things are needed for natural selection to happen
~variation among individuals
~number of offspring are different
~variation must be genetically inherited
what 4 diseases are advantages to be heterozygous of?
sickle cell anemia, cystic fibrosis (against TB and diarrhea), triosephosphate isomerase deficiency (against oxidative stress), diffuse presence of the HLA-DRB1 allele(against HCV infection progression to end stage liver disease)