Polyposis syndromes Flashcards
What type of colon polyp is this?
Hamartomatous polyp
Smooth muscle runs through the polyp
What type of colon polyp is this?
Juvenile polyp
cystic dilations of the crypts
edema and inflammation
1-2 solitary polyps= no malignant risk
>2 polyps = juvenile polyposis syndrome associated with colon and upper GI cancers
hyperplastic polyp
hyperplastic polyp
SSA
serrated crypts
flask shape neck of crypt is smaller than base of the crypt
SSA
Surveillance recommendations
Surveillance recommendations
Surveillance recommendations for subsequent exams
Traditional serrated polyp
KRAS/BRAF pathway
colon adenocarcinoma
Tubular adenoma on the right side of the slide
large and dark nuclei
tubulovillous adenoma
Spiegelman surveillance recommendations
Surveillance program for FAP, AFAP, and MutYH
Screening program for peuttz jagers syndrome
screening program for cowden
screening program for hereditary pancreatic cancer and gastric cancer
what are the polyp –> carcinoma pathways?
Name inheritance pattern and gene mutation
FAP
MAP
Peutz-Jeghers syndrome
Juvenille polyposis syndrome
Cowden syndrome
FAP- AD, APC
MAP- AR, MutYH
Peutz-Jeghers syndrome- AD, STK 11
Juvenille polyposis syndrome -AD, SMAD4, BMPR1A
Cowden syndrome- PTEN
Screening program for lynch syndrome
IC testing in cancers to r/o lynch syndrome
28yo M with painless rectal bleeding. When should he have surveillance colon?
Juvenile polyp
1-2 isolated polyps ok; doest not need to be under surveillance program.
3 -4 polyps is unclear
>5 meets criteria for juvenille polyposis syndrome
cystic architecture with mucus filled glands
Sigmoid volvulus
IV abx, endoscopic decompression followed by surgery to pexy the bowel in place
SSA
dilated and boot shaped crypts
SSA with dysplasia (on the right)
