Esophagus Flashcards
GERD, BE, H. pylori
How do you manage extraesophageal reflux symptoms?
How do you manage new symptoms of GERD?
How do you manage refractory GERD symptoms?
How do you manage new symptoms of extraesophageal reflux?
How do you manage non-cardiac chest pain?
- Cardiac evaluation
If reflux symptoms present, then PPI BID 8 to 12 weeks
If no reflux symptoms presents, then EGD or pH study
Can GERD be diagnosed off layngoscopy findings alone?
no
How do you manage GERD in pregnancy?
- lifestyle changes
- antacids, sucralfate
- H2 blockers or PPI (any except omeprazole)
How long do you continue PPI?
- stop PPI- GERD w/o erosive esophagitis or BE; patients whos symptoms resolved on PPI
- Indefinite treatment with PPI- LA grade C/D or BE
When should you use BRAVO vs impedence pH testing?
Is this GERD? - use any test OFF therapy to establish a diagnosis
This patient has GERD, why are they still symptomatic?- use impedance pH testing ON therapy because you can learn about non-acid reflux
Does 2CM BE confirm a diagnosis of GERD?
No.
Endoscopic finidings of GERD are LA grade C/ D or BE >3cm
LA grade B only if symtoms of GERD and response to PPI
What is the symptom index (SI)?
reflux-related symptoms / total # of symptom episodes
> 50% is significant
What is the symptom sensitivity index (SSI)
of reflux-related symptoms / total # of reflux events
> 10% is significant
What is the symptom association probability
p value for the test
> 95% is significant
What enzyme metabolizes PPI?
CYP2C19
Rabeprazole is least dependent
Are all PPIs equivalent?
what is superior to PPI?
All are clinically equivalent at healing esophagitis
All are NOT equivalent in lowering acid pH
Rabeprazole > esomeprazole> omeprazole > lansoprazole > pantoprazole
vonoprazan is highly effective for treating LA Grade A and B esophagitis, so is lansoprazole, and healing rates at 8 weeks are 100% versus 99.2%, respectively.
In contrast, vonoprazan healing of LA Grade C and D
What are the possible results of impedance pH study ON PP?
- inadequate acid suppression despite PPI
- non-acid reflux causes symptoms (hypersensitivity)
- normal pH study- functional, other condition (EOE, achalasia, gastroparesis, etc).